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卡维地洛防治肝硬化食管静脉曲张破裂出血的作用进展
Advances in the effect of carvedilol in prevention and treatment of esophageal variceal bleeding in patients with cirrhosis
文章发布日期:2017年12月09日  来源:  作者:牛晓卫,刘同亭,魏志  点击次数:53次  下载次数:7次

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【摘要】:卡维地洛作为新一代非选择性β受体阻断剂,其β受体阻滞作用已被证明是普萘洛尔的2~4倍,广泛应用于心力衰竭的有效治疗,然而其在降低肝门静脉压力、防治食管静脉曲张出血等方面是否发挥了同样的效用还存在争议。对比分析了卡维地洛与普萘洛尔、内镜下套扎在防治出血方面的临床应用研究,并总结了卡维地洛的药理作用、临床作用、应用剂量及不良反应,认为卡维地洛可显著改善门静脉高压的血流动力学紊乱,有望成为防治食管静脉曲张破裂出血的前沿药物。
【Abstract】:Carvedilol is a new non-selective beta blocker, and studies have proven that the effect of carvedilol in receptor blocking is 2-4 times that of propranolol. Carvedilol is widely used in the treatment of heart failure. However, there are still controversies over its effect in reducing portal pressure and preventing esophageal variceal bleeding. This article analyzes and compares the clinical application of carvedilol, propranolol, and endoscopic variceal ligation in the prevention and treatment of bleeding and summarizes the pharmacological action, clinical effect, dose, and adverse reactions of carvedilol. It is pointed out that carvedilol can significantly improve hemodynamic disorder caused by portal hypertension and thus may become a new drug for the prevention and treatment of esophageal variceal bleeding.
【关键字】:肝硬化;食管和胃静脉曲张;卡维地洛;治疗;综述
【Key words】:liver cirrhosis; esophageal and gastric varices; carvedilol; therapy; review
【引证本文】:NIU XW, LIU TT, WEI Z. Advances in the effect of carvedilol in prevention and treatment of esophageal variceal bleeding in patients with cirrhosis[J]. J Clin Hepatol, 2018, 34(1): 184-187. (in Chinese)
牛晓卫, 刘同亭, 魏志. 卡维地洛防治肝硬化食管静脉曲张破裂出血的作用进展[J]. 临床肝胆病杂志, 2018, 34(1): 184-187.

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