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原发性胆汁性胆管炎的动物模型
A study on animal models of primary biliary cholangitis
文章发布日期:2017年10月11日  来源:  作者:郝娟,刘成海  点击次数:203次  下载次数:49次

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【摘要】:理想的原发性胆汁性胆管炎(PBC)动物模型对于研究疾病的病理生理机制与药物研发等均有重要意义。近年来可反映血清抗线粒体抗体阳性与胆管免疫病理损伤等PBC特点的动物模型取得了较大进展。目前PBC动物模型的制备方式多样,包括化学或生物染毒诱导,以及基因敲除后自发形成。但上述模型尚无法完全模拟人类PBC,其血清学、免疫学、组织病理等方面也各有特点,提示PBC基因特异与环境改变的病理机制的复杂性,对认识免疫耐受性被打破和胆管上皮细胞受到特异性攻击等PBC早期事件的机制具有重要意义。
【Abstract】:An ideal animal model of primary biliary cholangitis (PBC) plays an important role in the research on physiopathological mechanism and drug research and development. In recent years, great achievements have been made in animal models which can reflect the features of PBC, such as positive serum anti-mitochondrial antibody and immunopathological injury of the bile duct. There are various methods for the preparation of animal models of PBC at present, including chemical or biological exposure and gene knockout. However, these models cannot completely simulate PBC in humans, since they have different serological, immunological, and histopathological features. This suggests the complexity of pathological mechanisms of PBC, including gene specificity and environmental changes and helps us to understand the pathogenesis of events in the early stage of PBC, such as the break of immune tolerance and specific attack of biliary epithelial cells.
【关键字】:胆管炎, 胆汁性; 模型, 动物
【Key words】:cholangitis, biliary; models, animal
【引证本文】:郝娟, 刘成海. 原发性胆汁性胆管炎的动物模型[J]. 临床肝胆病杂志, 2017, 33(11): 2117-2122.

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