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HBV感染与复制模型的建立及应用
Establishment and application of in vitro and in vivo models of hepatitis B virus infection
文章发布日期:2017年07月07日  来源:  作者:王宝菊,朱彬,杨东亮,等  点击次数:185次  下载次数:15次

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【摘要】:乙型肝炎是危害人类健康的重要传染病,目前的抗病毒治疗,如干扰素、核苷和核苷酸类药物仍无法治愈慢性乙型肝炎。因此,亟待阐明HBV复制和致病机制,探索新的治疗靶点,进而研发新的治疗药物或方案。合适的HBV感染与复制模型是上述研究的基础。由于HBV具有严格的种属限制性及组织亲嗜性,使得HBV感染与复制模型的研发受到一定限制。在国家传染病科技重大专项资助下,国内研究者建立了一系列的细胞和动物模型,就此并结合近年来国内外研究进展进行简要综述。
【Abstract】:Hepatitis B is still an important infectious disease which threatens human health, and current antiviral therapy, including interferon and nucleos(t)ide analogues, cannot cure chronic hepatitis B. Therefore, it is urgent to explore the detail mechanisms of HBV replication and pathogenesis, identify new therapeutic targets, and develop new drugs or treatment regimens, which relies on the development of suitable models for HBV infection and replication. Species restriction and tissue tropism of HBV have limited the development of models for HBV infection and replication. With the support by National Science and Technology Major Project for Infectious Diseases, the researchers in China have developed a series of cellular and animal models for HBV. This article reviews these models with reference to recent research advances in China and foreign countries.
【关键字】:肝炎病毒,乙型;细胞模型;疾病模型,动物
【Key words】:hepatitis B virus; cell model; disease models, animal
【引证本文】:王宝菊, 朱彬, 郭伟娜, 等. HBV感染与复制模型的建立及应用[J]. 临床肝胆病杂志, 2017, 33(8): 1458-1464.

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