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5-羟色胺在非酒精性脂肪性肝病发病机制及治疗中的作用
Role of 5-hydroxytryptamine in the pathogenesis and treatment of nonalcoholic fatty liver disease
文章发布日期:2017年05月04日  来源:  作者:金豆,牛春燕  点击次数:191次  下载次数:36次

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【摘要】:非酒精性脂肪性肝病(NAFLD)的患病率不断上升, 其发病机制复杂且尚未完全阐明,迄今仍缺乏诊断及治疗的金标准,5-羟色胺可以从多个环节影响NAFLD的发生、发展,改变NAFLD的疾病进程。现从能量代谢、肠道通透性及肠道菌群失调、肝脏再生的角度阐述5-羟色胺与NAFLD的相关性及其在NAFLD发病机制中的作用及治疗中的应用前景。
【Abstract】:The prevalence rate of nonalcoholic fatty liver disease (NAFLD) has been increasing year by year. However, since the complex pathogenesis of NAFLD has not been fully clarified, there still lacks a gold standard for the diagnosis and treatment of NAFLD. 5-Hydroxytryptamine (5-HT) can affect the development and progression of NAFLD via several links and thus change the course of NAFLD. This article introduces the association between 5-HT and NAFLD, the role of 5-HT in the pathogenesis of NAFLD, and its future application in treatment.
【关键字】:脂肪肝; 血清素; 综述
【Key words】:fatty liver; serotonin; review
【引证本文】:金豆, 牛春燕. 5-羟色胺在非酒精性脂肪性肝病发病机制及治疗中的作用[J]. 临床肝胆病杂志, 2017, 33(6): 1169-1172.

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