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抗HBV药物的研制进展及方向.
Direction and progress in research and development of anti-HBV drugs
文章发布日期:2016年05月06日  来源:  作者:冷雪君,张莹,申姣春,等  点击次数:1701次  下载次数:305次

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【摘要】:慢性乙型肝炎(CHB)是全球公众健康的首要危险因素,并且是潜在疾病进展为肝硬化和肝细胞癌(HCC)的主要病因。但迄今为止治疗这种致死性病毒感染的方法却极少,且治疗效果尚不理想。目前人们已经意识到发展新型药物的必要性,综述了目前市场上所有可用的及处于临床试验的药物,介绍了每类抗HBV药物中未来发展前景可能可观的几种治疗药物。指出未来抗HBV药物多效联合用药的发展方向,并为HBV研究者或从事卫生保健工作的专家提供最新的HBV治疗进展。
【Abstract】:Abstract:Chronic hepatitis B (CHB) is considered as the most important risk factor for public health around the world, as well as the main reason for potential diseases to develop into liver cirrhosis and hepatocellular carcinoma. However up to now, there are few methods for the treatment of this lethal viral infection with poor therapeutic effects. At present, we have realized the necessity to develop new drugs. This article reviews the drugs currently available in market or under clinical trials, introduces several drugs with a promising future in each category of anti-HBV drugs, and points out the developmental direction of multi-effect combination of anti-HBV drugs in future, in order to provide the latest advances in HBV treatment for researchers working on HBV and experts engaged in healthcare.
【关键字】:肝炎病毒,乙型;抗病毒药;综述
【Key words】:hepatitis B virus;antiviral agents; review
【引证本文】:冷雪君, 张莹, 申姣春, 等. 抗HBV药物的研制及进展方向[J]. 临床肝胆病杂志, 2016, 32(6): 1199-1103.

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