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162例慢性乙型重型肝炎医院感染调查分析
Nosocomial infections and chronic severe hepatitis B: A clinical study of 162 patients
文章发布日期:2012年06月12日  来源:  作者:朱其荣  点击次数:2063次  下载次数:400次

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【摘要】:目的分析总结慢性乙型重型肝炎患者发生医院感染的特点,为加强医院感染的防控提供帮助。方法调查分析我院2008年1月至2011年10月收治的慢性乙型重型肝炎患者162例发生医院感染的情况。结果162例慢性乙型重型肝炎患者中发生医院感染35例,医院感染率为21.6%。感染部位以腹腔感染和呼吸道感染最多,其次为肠道感染。病原菌以大肠埃希菌和肺炎克雷伯杆菌常见。医院感染主要发生在住院时间15~30 d,占72.09%。医院感染组治疗无效率(20%)显著高于非医院感染组(7.09%)(P<0.05)。结论慢性乙型重型肝炎医院感染发生率高,应积极治疗原发病,改善肝功能,严格遵守消毒隔离制度,加强医院感染的防控,从而提高生存率。
【Abstract】:ObjectiveTo analyze and summarize the characteristics of nosocomial (hospital-acquired) infections experienced by chronic severe hepatitis B patients in order to strengthen prevention and control strategies. MethodsChronic severe hepatitis B patients treated in our hospital from January 2008 to October 2011 were retrospectively enrolled in the study. Cases of nosocomial infections were statistically analyzed by the Chi-squared test. ResultsOf the 162 patients with chronic severe hepatitis B, only 35 experienced nosocomial infections, yielding an infection rate of 21.6%. The most common infection sites were the abdominal cavity (41.86%), the respiratory system (2326%), and the intestine (16.28%). Escherichia coli and Klebsiella pneumoniae were the most commonly detected pathogens (2963% and 18.52% of cases, respectively). The rates of nosocomial infections were highest between days 15 to 30 of the hospital stay, accounting for 72.1%. The overall invalid rate and rate of death (expressed as a summed rate of ineffectivity) was significantly higher in the nosocomial infection group than in the non-nosocomial group (20.0% vs 7.1%, respectively; P<0.05). ConclusionThe rate of nosocomial infections in chronic severe hepatitis B patients is high. Patients with chronic severe hepatitis B should be treated to resolve the primary disease, so as to improve liver function and general health; however, strict compliance with disinfection and hygeinic practices, as well as possible patient isolation, may decrease the incidence rate of nosocomial infections and improve survival in this patient population.
【关键字】:肝炎,乙型,慢性;交叉感染
【Key words】:hepatitis B, chronic;cross infection
【引证本文】:

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