首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 在线期刊 2008年 => 2期 =>乙型肝炎患者血清趋化因子CXCL..
乙型肝炎患者血清趋化因子CXCL16的检测及其意义
The assay and significance of CXCL16 in serum of hepatitis B patients.
文章发布日期:2009年09月29日  来源:  作者:杨勇; 刘佩芝; 詹爱琴   点击次数:1497次  下载次数:680次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】: 目的探讨乙肝患者血清趋化因子CXCL16的变化规律及其临床意义。方法用酶联免疫吸附法(ELISA)检测血清CXCL16浓度;荧光定量聚合酶链反应法(FQ-PCR)检测HBV-DNA;全自动生化仪检测肝功能。结果对照组(n=25)、急性乙肝组(n=24)、慢性乙肝组(n=32)CXCL16浓度分别为1.676±0.766(ng/ml)、2.150±0.714(ng/ml)、2.417±0.537(ng/ml)。急、慢性乙肝组CXCL16浓度显著高于对照组(P值分别为0.015、0.000)。急、慢性乙肝组之间比较,差异无统计学意义(P=0.142)。HBeAg阳性乙肝组(n=26)与HBeAg阴性乙肝组(n=30)比较,差异无统计学意义(P=0.741)。CXCL16浓度与ALT水平无相关性(r=-0.46,P=0.736),与HBVDNA拷贝数也无相关性(r=-0.191,P=0.158),但CXCL16有随病情加重而增高的趋势。结论CXCL16可能参与了乙肝的炎症损伤机制;ALT、HBVDNA及HBeAg与CXCL16浓度变化无明显相关。
【Abstract】:Objective To investigate the change and clinical significance of serous chemokine CXCL16 in patients with hepatitis B.Methods The serous concentration of CXCL16 was detected by enzyme linked immunosorbent assay(ELISA);HBV-DNA was detected by fluorescent quantitive polymerase chain reaction(FQ-PCR);Liver function was assayed by automatic biochemistry analyzer.Results Concentration of serous CXCL16 in normal group(n=25)、AHB(acute hepatitis B) group(n=24) and CHB(chronic hepatitis B) group(n=32) was 1.676±0.766(ng/ml)、2.150±0.714(ng/ml) and 2.417±0.537(ng/ml)respectively.The concentration of CXCL16 in AHB and CHB groups were both significantly higher than that of normal group,(P=0.015,0.000,respectively).However,the disparity of CXCL16 concentration between AHB and CHB group isn't statistically significant(P=0.142).Likewise,no statistical significance of the difference of CXCL16 was found between HBeAg positive(n=26) and negative(n=30) patients group(P=0.741).There is no correlation betwe
【关键字】:趋化因子; CXCL16; 乙型肝炎
【Key words】:chemokine; CXCL16; hepatitis B
【引证本文】:

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号