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慢性肝病、肝癌患者IL-6、IL-8和TNF-α活性测定及意义
Interleukin6、Interleukin8 and Tumor necrosis factorα activity in patients with chronic hepatitis,hepatocirrhosis and hepatocellular carcinoma 
文章发布日期:2009年10月26日  来源:  作者:  点击次数:1527次  下载次数:692次

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【摘要】:本文对36例慢性肝炎(CH)、28例肝炎性肝硬化及29例原发性肝癌患者血清中IL6、IL8及TNFα活性进行了测定。结果表明,慢性肝炎患者IL6、IL8及TNFα活性分别为:180.54±9.68,160.88±6.16和230.74±89.04pg/ml,明显高于对照组(P<0.01);肝炎性肝硬化患者IL6、IL8及TNFα活性分别为246.67±9.06,203.04±8.02和267.85±106.88pg/ml,明显高于对照组(P<0.001);原发性肝病患者IL6和IL8活性分别为101.11±8.64和107.46±4.58pg/ml,与对照组比较,活性明显升高(P<0.05),TNFα活性为306.78±158.66pg/ml,明显高于对照组(P<0.01),并对上述三种细胞因子与慢性肝炎、肝硬化及肝癌的发生发展关系进行了探讨。
【Abstract】:The activity of interleukin 6(IL6),interleukin 8(IL8) and tumor necrosisfactoralpha (TNF) in the sera from patients with chronic hepatitis(CH),hepatocirrhosis(HC) and hepatocellular carcinoma(HCC) was detected.The results indicated that IL6,IL8 and TNFα in sera from patients with CH was 18054±968;16088±616 and 23074±8904 pg/ml respectively which were significantly higher than those of normal controlsthat IL6,IL8 and TNFα activity in sera from patients with HC was 24667±906,20304±802 and 26785±10688 pg/ml respectively which were significantly higher than those of normal controls and that IL6,IL8 and TNFα activity in sera from patients with HCC were significantly higher those of normal controls.The relationship among IL6,IL8 and TNF-α activity with immunodamaage of CH and HC,HCC of liver disease was also investigated.
【关键字】:细胞因子; 慢性肝炎; 肝炎性肝硬化; 原发性肝癌
【Key words】:Cytokines Chronic Hepatitis Hepatocirrhosis Hepatcellular carcinoma
【引证本文】:

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