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脾切除有助于纠正肝硬化患者氧化和抗氧化的失衡
Splenectomy is helpful to correct unbalance between oxidation and antioxidation in patients with Liver cirrhosis
文章发布日期:2009年10月20日  来源:  作者:陆新良; 朱志鑫; 蔡建庭; 唐训球; 钱可大; 周君富  点击次数:2760次  下载次数:767次

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【摘要】:探讨脾切除对肝硬化患者氧化和抗氧化系统的影响及其临床意义。测定 2 8例肝硬化脾切除患者、32例肝硬化非脾切除患者和 6 0例正常人血浆维生素C(P -VitC) ,维生素E(P -VitE) ,β-胡萝卜素 (P - β-CAR)和一氧化氮 (P -NO)含量 ,红细胞超氧化物歧化酶 (E -SOD)、过氧化氢酶 (E -CAT)和谷胱甘肽过氧化物酶 (E -GSH -Px)活力 ,血浆及红细胞过氧化脂质 (P -LPO ,E -LPO)水平的变化。肝硬化非脾切除组、脾切除组和对照组的P -VitC、P -VitE、P - β -CAR、E -SOD、E -CAT和E -GSH -Px水平依次升高 (均P <0 0 0 1) ;三组的P -NO、P -LPO和E -LPO含量依次降低 (均P <0 0 0 1)。除了脾切除组和对照组E -SOD差异无统计学意义外 ,三组之间其他检测值的两两比较均有统计学意义。脾切除有利于纠正肝硬化患者体内一氧化氮代谢异常、氧化和抗氧化的失衡。
【Abstract】:To assess the effects of splenectomy in liver cirrhosis on oxidant and antioxidant system and its clinical significance. The plasma levels of vitamin E (P-Vit E), vitamin C (P-Vit C), beta-carotene (P-β-CAR), lipoperoxides (P-LPO) and nitric oxide (P-NO), the erythrocyte levels of superoxide dismutase (E-SOD), catalase (E-CAT), glutathione peroxidase (E-GSH-Px) and E-LPO in cirrhosis patients were measured in 28 liver cirrhosis patients with splenectomy, 32 without splenectomy, 60 sex-and age-matched subjects from healthy people as the control group. It showed that the levels of P-Vit E, P-β-CAR and P-Vit C as well as activity of E-SOD, E-CAT and E-GSH-Px gradually increased in cirrhosis without splenectomy group, in cirrhosis with splenectomy group and in normal control group (all P <0 001); While the contents of P-LPO, E-LPO and P-NO gradually decreased (all P <0 001). Multiple comparisons showed there were statistical difference among three groups ( P <0 001, P <0 01 or
【关键字】:肝硬化; 脾切除术; 一氧化氮; 抗氧化维生素; 抗氧化酶; 过氧化脂质
【Key words】:Liver cirrhosis; Splenectomy; Nitric oxide; Antioxidant vitamin; Antioxidase; Lipoperoxides
【引证本文】:

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