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苦参碱联合肝炎灵注射液治疗慢性乙型肝炎临床观察
Clinical observation on treatment of chronic hepatitis B with Injectio Matrini and "Ganyanling" injection.
文章发布日期:2009年10月20日  来源:  作者:郑有章; 何有成; 黄康民  点击次数:1531次  下载次数:684次

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【摘要】:探讨中草药制剂苦参碱注射液和肝炎灵注射液在慢性乙型肝炎抗病毒治疗方面的疗效。将 10 6例慢性乙型肝炎患者分为治疗组 5 8例和对照组 4 8例 ,治疗组应用苦参碱注射液 15 0mg加入 10 %葡萄糖溶液中静脉滴注 ,同时联合应用肝炎灵注射液 70mg肌肉注射 ,每日一次 ,疗程 12周。治疗前后各检测肝功能 ,HBsAg、HBeAg及HBV-DNA。治疗组HBeAg、HBV -DNA阴转率分别为 39 7% (2 3/ 5 8)、4 1 4 % (2 4 / 5 8) ,对照组两者皆 14 6 % (7/ 4 8)差异显著 (P <0 0 1)。治疗组ALT、AST复常率亦显著高于对照组 (P <0 0 5 )。苦参碱联合肝炎灵注射液能有效抑制乙肝病毒 (HBV)的复制 ,是治疗慢性乙型肝炎安全有效的药物。
【Abstract】:To study the curative effect of Chinese herbal preparation, injectio matrini and "Ganyanling" injection on the anti-virus treatment of chronic hepatitis B. 106 cases with chronic hepatitis B were divided into treatment group and control group (58 cases for treated group and 48 cases for control group). Drip infusion technique by adding 150 mg injectio matrini into 10% dextrose solution was adopted in treatment group. Intramuscular injection with 70 mg "Ganyanling"was given daily at the same time with a course of 12 weeks. Liver function, HBsAg,HBeAg and HBV-DNA were tested both before and after the treatment. In treatment group, the negative transforming rate of HBeAg and HBV-DNA were 39 7%(23/58) and 41 4%(24/58) respectively, which were much higher than the both 14 6%(7/48) ( P <0 01) in control group. The ALT and AST recovery rates in treatment group were much higher than those in control group ( P <0 05). Injectio matrini used together with "Ganyanling" injection may effectiv
【关键字】:中草药治疗; 慢性乙型肝炎; 病毒
【Key words】:Chinese herbal treatment; Chronic hepatitis B; Virus
【引证本文】:

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