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胆囊癌组织中树突状细胞与PCNA表达及意义
Dentritic cell infiltration and PCNA expression in gallbladder carcinoma and their significances.
文章发布日期:2009年10月20日  来源:  作者:张明威; 张静; 赵征红   点击次数:1545次  下载次数:634次

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【摘要】:研究胆囊组织中树突状细胞 (DC)浸润程度和增殖细胞核抗原 (PCNA)表达与浸润、转移的关系并探讨DC和PCNA表达的相关性。用免疫组化SP法检测 4 6例胆囊癌组织S - 10 0阳性标记的DC数量和PCNA表达。在胆囊癌中S - 10 0蛋白阳性的DC和PCNA阳性表达率分别为 5 2 2 %和 6 9 6 %。DC浸润与胆囊癌的浸润程度和淋巴结转移呈负相关 (P <0 0 5 ) ,PCNA表达与胆囊癌的浸润程度和淋巴结转移呈正相关 (P <0 0 5 ) ,DC与PCNA表达呈明显负相关 (P <0 0 5 )。DC和PCNA表达与胆囊癌的侵袭和淋巴结转移密切相关。
【Abstract】:To evaluate the dentritic cell infiltration and PCNA expression and their signifcances in gallbladder carcinoma.46 cases of gallbladder carcinoma were examined by immunohistochemical method to detect the infiltration of S-100 protein-postive dentritic cells and PCNA expression.The positive expression rates of DC and PCNA were 52 2% and 69 6% in gallbladder carcinoma respectively.DC infiltration was negatively correlated with invasion and lymph node metastasis.The expression of PCNA was positively correlated with invasion and lymph node metastasis.There was negative correlation between the degree of DC infiltration and PCNA expression.The results suggested that DC infiltration and PCNA expression may play an important role invasion and lymph node matastasis in gallbladder carcinoma.
【关键字】:胆囊肿瘤; 树突状细胞; 增殖细胞抗原; 免疫组织化学
【Key words】:Gallbladder Carcinoma; Dentritil cell; PCNA; Immunohistochemical method
【引证本文】:

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