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【摘要】：实现慢性乙型肝炎患者临床终点事件的精准预测，确定肝硬化失代偿及肝细胞癌的高危患者，进而加强干预降低相应病死率，具有重要的临床意义。基于目前已发表的慢性乙型肝炎患者临床终点事件的预测模型，主要从方法学角度阐述预测模型构建的思路及基本步骤，以期为乙型肝炎领域预测模型相关研究提供参考。
【Abstract】：It is of great clinical significance to achieve accurate prediction of clinical endpoints in patients with chronic hepatitis B (CHB), identify the patients at a high risk of decompensated cirrhosis or hepatocellular carcinoma, and thus strengthen intervention to reduce the corresponding mortality rate. With reference to the published predictive models for clinical endpoints in CHB patients, this article elaborates on the thoughts and basic steps of establishing predictive models from the aspect of methodology, hoping to provide a reference for future studies on predictive models for hepatitis B.
【关键字】：乙型肝炎，慢性； 肝硬化； 癌，肝细胞； 模型，统计学
【Key words】：hepatitis B，chronic； liver cirrhosis； carcinoma，hepatocellular； models，statistical
【引证本文】：WU SS, KONG YY. Methodology of establishing predictive models for clinical endpoints in patients with chronic hepatitis B［J］. J Clin Hepatol, 2020, 36(9): 1923-1927. (in Chinese)
武珊珊， 孔媛媛. 构建慢性乙型肝炎临床终点事件预测模型的方法学考量［J］. 临床肝胆病杂志, 2020, 36(9): 1923-1927.