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您现在的位置:首页 => 在线期刊 => 2020年 7期“炎症性肠病与肝胆胰疾病” => 其他肝病 =>维生素E治疗儿童非酒..
维生素E治疗儿童非酒精性脂肪性肝病效果的Meta分析
Clinical effect of vitamin E in treatment of nonalcoholic fatty liver disease in children: A Meta-analysis
文章发布日期:2020年06月08日  来源:  作者:刘申申,邢怡青,王宁,等  点击次数:283次  下载次数:36次

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【摘要】:目的 评估维生素E对儿童非酒精性脂肪性肝病(NAFLD)的治疗效果。方法 检索2019年12月前发表的关于维生素E治疗儿童NAFLD疗效的文章,检索范围包括PubMed、Web of Science、The Cochran Library、Embase、OVID/NEJM、中国知网、万方数据库。分析数据包含BMI、肝酶水平(ALT、AST)、血脂水平(TG、TC、LDL、HDL)、肝脂肪变性缓解率共8个参数。使用REVMAN 5.3进行Meta分析。连续变量选择标准化均数差(SMD)和95%可信区间(CI)计算和分析干预前后参数的差异,分类变量选择风险差(RD)和95%CI进行分析。非异质性数据采用固定效应模型,否则采用随机效应模型。发表偏倚的评估通过漏斗图完成。结果 共检索到599篇文章,其中9篇纳入Meta分析,受试者607例。维生素E显著改善了患儿的ALT水平(SMD=-0.27,95%CI:-0.48~-0.06,P=0.01),但是对患儿的BMI水平(SMD=-0.09,95%CI:-0.28~0.10,P=0.34)、AST水平(SMD=-0.20,95%CI:-0.42~0.02,P=0.07)、TG水平(SMD=-0.19,95%CI:-0.51~0.12,P=0.22)、TCHO水平(SMD=-0.11,95%CI:-0.31~0.08,P=0.24)、HDL(SMD=-0.02,95%CI:-0.27~0.23,P=0.88)、LDL水平(SMD=-0.04,95%CI:-0.27~0.19,P=0.72)、肝脂肪变性缓解率(RD= 0.06,95%CI:-0.05~0.17,P=0.29)无显著改善。结论 维生素E能够显著改善儿童NAFLD患者的ALT水平,可考虑作为临床辅助用药。
【Abstract】:Objective To investigate the clinical effect of vitamin E in the treatment of nonalcoholic fatty liver disease (NAFLD) in children. Methods PubMed, Web of Science, The Cochran Library, Embase, OVID/NEJM, CNKI, and Wanfang Data were searched for the articles on vitamin E in the treatment of NAFLD in children published up to December 2019. The data of 8 parameters were analyzed, i.e., body mass index (BMI), liver enzymes [alanine aminotransferase (ALT) and aspartate aminotransferase (AST)], blood lipid levels [triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL)], and remission rate of hepatic steatosis. RevMan 5.3 was used to perform a Meta-analysis. Continuous variables were analyzed by standardized mean difference (SMD) and 95% confidence interval (CI), and the changes after intervention were analyzed; categorical variables were analyzed by risk difference (RD) and 95%CI. A fixed effects model was used for homogeneous data, and a random effects model was used for heterogeneous data. Funnel plots were used to evaluate publication bias. Results A total of 599 articles were retrieved, among which 9 were included in the Meta-analysis, with 607 subjects in total. Vitamin E significantly improved the level of ALT (SMD = -0.27, 95%CI: -0.48 to -0.06, P=0.01), but it did not improve the levels of BMI (SMD=-0.09, 95%CI: -0.28 to 0.10, P=0.34), AST (SMD=-0.20, 95%CI: -0.42 to 0.02, P=0.07), TG (SMD=-0.19, 95%CI: -0.51 to 0.12, P=0.22), TCHO (SMD=-0.11, 95%CI: -0.31 to 0.08, P=0.24), HDL (SMD=-0.02, 95%CI: -0.27 to 0.23, P=0.88), LDL (SMD= -0.04, 95%CI: -0.27 to 0.19, P=0.72), and the remission rate of hepatic steatosis (RD=0.06, 95%CI: -0.05 to 0.17, P=0.29). Conclusion Vitamin E can significantly improve the level of ALT in children with NAFLD and can be considered as an adjuvant drug for clinical treatment.
【关键字】:非酒精性脂肪性肝病; 维生素E; 儿童; Meta分析(主题)
【Key words】: non-alcoholic fatty liver disease; vitamin E; child; Meta-analysis as topic
【引证本文】:LIU SS, XING YQ, WANG N, et al. Clinical effect of vitamin E in treatment of nonalcoholic fatty liver disease in children: A Meta-analysis[J]. J Clin Hepatol, 2020, 36(7): 1545-1550. (in Chinese)
刘申申, 邢怡青, 王宁, 等. 维生素E治疗儿童非酒精性脂肪性肝病效果的Meta分析[J]. 临床肝胆病杂志, 2020, 36(7): 1545-1550.

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