首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2020年 7期“炎症性肠病与肝胆胰疾病” => 专家论坛 =>炎症性肠病与慢性肝脏..
炎症性肠病与慢性肝脏疾病的关系及其管理策略
Association between inflammatory bowel disease and chronic liver diseases and related management strategies
文章发布日期:2020年06月08日  来源:  作者:王江滨  点击次数:361次  下载次数:76次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:炎症性肠病(IBD)在多种情况下都可以合并慢性肝脏疾病。IBD与包括原发性硬化性胆管炎、原发性胆汁性胆管炎、自身免疫性肝炎在内的自身免疫性肝病在发病机制上有重叠因素,故合并存在的现象并不少见,其中原发性硬化性胆管炎合并IBD的几率最高,可达80%以上;IBD合并慢性HBV/HCV感染的几率与当地的感染率相关,若在应用免疫抑制剂之前忽略了对HBV/HCV感染的筛查,则存在HBV/HCV感染加重或HBV再激活的发生风险;IBD患者在长期治疗中应用的抗生素、类固醇激素类药物、免疫抑制剂时有诱导药物性肝损伤的可能;尽管IBD患者常因腹泻、吸收障碍等因素导致消瘦,但其合并非酒精性脂肪性肝病的几率却明显高于当地一般人群。
【Abstract】:Inflammatory bowel disease (IBD) is often accompanied by chronic liver diseases in a variety of situations. Due to the overlapping factors in the pathogenesis of IBD and autoimmune liver diseases including primary sclerosing cholangitis (PSC), primary biliary cholangitis, and autoimmune hepatitis, the co-existence of these diseases is not uncommon, among which PSC with IBD has the highest probability of more than 80%. The probability of IBD with chronic hepatitis B virus (HBV)/hepatitis C virus (HCV) infection is associated with local infection rate, and if the screening for HBV/HCV infection is ignored before the application of immunosuppressive agents, there may be a risk of aggravated HBV/HCV infection or HBV reactivation. Long-term treatment with antibiotics, steroids, and immunosuppressants may cause drug-induced liver injury in patients with IBD. Although IBD patients often have weight loss due to the factors including diarrhea and absorption disorders, these patients may have a higher probability of nonalcoholic fatty liver disease than the general population.
【关键字】:炎症性肠病; 肝疾病; 诊断; 治疗学
【Key words】:inflammatory bowel disease; liver diseases; diagnosis; therapeutics
【引证本文】:WANG JB. Association between inflammatory bowel disease and chronic liver diseases and related management strategies[J]. J Clin Hepatol, 2020, 36(7): 1444-1449. (in Chinese)
王江滨. 炎症性肠病与慢性肝脏疾病的关系及其管理策略[J]. 临床肝胆病杂志, 2020, 36(7): 1444-1449.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号