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非酒精性脂肪性肝病相关肝细胞癌的发病机制
Research advances in the pathogenesis of nonalcoholic fatty liver disease-related hepatocellular carcinoma
文章发布日期:2020年06月01日  来源:  作者:罗燕,施军平  点击次数:214次  下载次数:84次

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【摘要】:非酒精性脂肪性肝炎/非酒精性脂肪性肝病(NASH/NAFLD)已经逐渐发展成为西方发达国家肝细胞癌(HCC)的主要病因之一。不同于经典的肝炎-肝硬化-肝癌疾病演变过程,近40%的NAFLD相关HCC可不经历肝硬化直接进展为HCC,表明其可能有不同的发病机制。阐述了关于NAFLD相关HCC发病机制的最新研究进展。
【Abstract】:Nonalcoholic steatohepatitis (NASH)/nonalcoholic fatty liver disease (NAFLD) has gradually become one of the main causes of hepatocellular carcinoma (HCC) in Western developed countries. Different from the typical evolution process of hepatitis, liver cirrhosis, and liver cancer, nearly 40% NAFLD patients can progress into HCC without experiencing liver cirrhosis, suggesting other mechanisms may play a role in this process. This article elaborates on the latest research advances in the pathogenesis of NAFLD-related HCC.
【关键字】:非酒精性脂肪性肝病; 癌,肝细胞; 肝硬化; 代谢; 细胞重新编程
【Key words】:non-alcoholic fatty liver disease; carcinoma,hepatocellular; liver cirrhosis; metabolism; cellular reprogramming
【引证本文】:LUO Y, SHI JP. Research advances in the pathogenesis of nonalcoholic fatty liver disease-related hepatocellular carcinoma[J]. J Clin Hepatol, 2020, 36(6): 1217-1220. (in Chinese)
罗燕, 施军平. 非酒精性脂肪性肝病相关肝细胞癌的发病机制[J]. 临床肝胆病杂志, 2020, 36(6): 1217-1220.

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