首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2020年 6期“非酒精性脂肪性肝病与多代谢紊乱的基础与临床” => 专家论坛 =>非酒精性脂肪性肝病更..
非酒精性脂肪性肝病更名的临床意义
Clinical significance of renaming nonalcoholic fatty liver disease
文章发布日期:2020年06月01日  来源:  作者:曾静,范建高  点击次数:293次  下载次数:136次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:非酒精性脂肪性肝炎和非酒精性脂肪性肝病(NAFLD)在20世纪80年代首次用于描述肝组织学改变与酒精性肝病相似但患者无过量饮酒且无其他损肝因素存在。40年来,NAFLD的研究越来越深入且进展迅速。然而,一直未变的NAFLD命名对日常临床实践和当前临床试验已产生了一定的阻碍。为了克服旧术语的缺陷,日前国际共识小组建议应用代谢相关脂肪性肝病(MAFLD)取代NAFLD,并进一步提出既全面又简便的MAFLD新定义用于临床诊断,从而使MAFLD有别于其他肝脏疾病;同时,建议MAFLD的疾病评估和严重程度分层应该超出当前的二分类法则。NAFLD更名为MAFLD将成为优化临床实践,提高临床研究效率,并使医生、患者群体获益的一项重要举措。
【Abstract】:The terms nonalcoholic steatohepatitis and nonalcoholic fatty liver disease (NAFLD) were first used in the 1980s to describe a condition of similar liver histological changes to alcoholic liver disease, without excessive drinking nor other factors for liver injury. In-depth research on NAFLD has achieved rapid progress over the past 40 years; however, the unchanged nomenclature of the disease has become an obstacle for routine clinical practice and clinical trials. To overcome the shortcomings of the old term, the international consensus panel proposes to use the term metabolic associated fatty liver disease (MAFLD) to replace NAFLD and further puts forward the comprehensive and simple definition of MAFLD for clinical diagnosis, which makes MAFLD different from other liver diseases. Meanwhile, the panel suggests that MAFLD assessment and severity stratification should be extended beyond the simple dichotomous classification used at present. The new name MAFLD will become an important measure for optimizing clinical practice and improving clinical research and may bring benefits to physicians and patients.
【关键字】:非酒精性脂肪性肝病; 代谢相关脂肪性肝病; 科学术语(主题)
【Key words】:non-alcoholic fatty liver disease; metabolic associated fatty liver disease; terminology as topic
【引证本文】:ZENG J, FAN JG. Clinical significance of renaming nonalcoholic fatty liver disease[J]. J Clin Hepatol, 2020, 36(6): 1205-1207. (in Chinese)
曾静, 范建高. 非酒精性脂肪性肝病更名的临床意义[J]. 临床肝胆病杂志, 2020, 36(6): 1205-1207.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号