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药物性肝损伤的研究进展
Research advances in drug-induced liver injury
文章发布日期:2020年03月19日  来源:  作者:杨雪,涂荣芳,杨晋辉  点击次数:400次  下载次数:214次

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【摘要】:药物性肝损伤(DILI)发病机制复杂、个体差异较明显。DILI发生早期诊治预后较好,但由于DILI无明显的特殊临床症状,多不能于早期发现,当错过最佳治疗时间后,可能进展为不可逆的肝衰竭,病死率升高,且晚期DILI除肝移植外并无有效的治疗方法。因此,对DILI患者早期做出诊断、治疗至关重要。总结了近年来DILI的相关进展,包括可疑药物、危险因素、发病机制、病理特点、临床分型和表现、诊断标准及评估、网络数据库研究等,以期为DILI的早期诊断、临床分型、指导治疗、判断预后等提供依据。
【Abstract】:Drug-induced liver injury (DILI) has a complex pathogenesis and obvious individual difference. Early diagnosis and treatment of DILI may achieve good prognosis, but due to a lack of specific clinical symptoms, most cases cannot be identified in the early stage. If no timely treatment is given, DILI may progress to irreversible liver failure with a high mortality rate, and there are no effective therapies for advanced DILI except liver transplantation. Therefore, early diagnosis and treatment are of great importance for patients with DILI. This article summarizes the recent research advances in DILI, including suspected drugs, risk factors, pathogenesis, pathological features, clinical types and manifestations, diagnostic criteria and evaluation, and network database, in order to provide a basis for early diagnosis, clinical typing, treatment guidance, and prognostic evaluation of DILI.
【关键字】:药物性肝损伤; 病理状态, 体征和症状; 危险因素; 诊断
【Key words】:drug-induced liver injury; pathological conditions, signs and symptoms; risk factors; diagnosis
【引证本文】:YANG X, TU RF, YANG JH. Research advances in drug-induced liver injury[J]. J Clin Hepatol, 2020, 36(3): 509-513. (in Chinese)
杨雪, 涂荣芳, 杨晋辉. 药物性肝损伤的研究进展[J]. 临床肝胆病杂志, 2020, 36(3): 509-513.

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