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大学教师胆结石患病现状及危险因素的多中心研究
Prevalence of gallstones among university teachers and related risk factors: A multicenter study
文章发布日期:2020年02月17日  来源:  作者:张弛,胡舒铃,孙鹏,等  点击次数:132次  下载次数:29次

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【摘要】:目的 研究天津市大学教师胆结石的患病率及其危险因素。方法 收集2015年在天津医科大学肿瘤医院健康体检中心参加体检的五所高校教师的体检数据,采用腹部超声对胆结石进行诊断。计数资料组间比较采用χ2检验。采用单因素及多因素logistic回归法分析不同大学胆结石患病的独立危险因素,并采用Meta分析的方法对不同大学教师患病率及危险因素进行合并。结果 共纳入大学教师8006人,其中440人被诊断为胆结石,合并后胆结石患病率为5.5%。Meta分析结果显示,高血压[比值比(OR)=1.67,95%可信区间(95%CI):1.32~2.12,P<0.001]、脂肪肝(OR=1.39,95%CI: 1.12~1.72,P<0.001)、肾结石(OR=1.90,95%CI:1.15~3.14, P=0.01)、较高水平的己糖激酶(OR=1.42,95%CI: 1.03~1.94,P=0.03)、较高水平的ALT(OR=1.32,95%CI: 1.01~1.73,P=0.04)和高球蛋白水平(OR=1.74,95%CI: 1.08~2.79,P=0.02)是胆结石的危险因素。结论 天津高校教师胆结石患病率相对较低,高血压、脂肪肝、肾结石、较高水平的己糖激酶以及ALT和球蛋白可能是胆结石患病的危险因素。
【Abstract】:Objective To investigate the prevalence rate of gallstones among university teachers in Tianjin, China, and related risk factors. Methods Physical examination data were collected from the teachers from five universities who participated in physical examination in Physical Examination Center, Tianjin Medical University Cancer Institute and Hospital, in 2015, and abdominal ultrasound was used for the diagnosis of gallstones. The chi-square test was used for comparison of categorical data between groups. Univariate and multivariate logistic regression analyses were used to identify the risk factors for gallstones in the teachers from different universities, and a meta-analysis was used for the pooled analysis of prevalence rate and risk factors. Results A total of 8006 university teachers were enrolled, among whom 440 were diagnosed with gallstones, and the pooled prevalence rate of gallstones was 5.5%. The meta-analysis showed that hypertension (odds ratio [OR]=1.67, 95% confidence interval [CI]: 1.32-2.12, P<0.001), fatty liver (OR=1.39, 95%CI: 1.12-1.72, P<0.001), kidney stones (OR=1.90, 95%CI: 1.15-3.14, P=0.01), and high levels of hexokinase (OR=1.42, 95%CI: 1.03-1.94, P=0.03), alanine aminotransferase (OR=1.32, 95%CI: 1.01-1.73, P=0.04), and globulin (OR=1.74, 95%CI: 1.08-2.79, P=0.02) were risk factors for gallstones. Conclusion There is a relatively low prevalence rate of gallstones among university teachers in Tianjin, and hypertension, fatty liver, kidney stones, and high levels of hexokinase, alanine aminotransferase, and globulin may be the risk factors for gallstones.
【关键字】:胆结石; 危险因素; 高校教师; 多中心研究(主题)
【Key words】:cholelithiasis; risk factors; college teachers; multicenter studies as topic
【引证本文】:ZHANG C, HU SL, SUN P, et al. Prevalence of gallstones among university teachers and related risk factors: A multicenter study[J]. J Clin Hepatol, 2020, 36(3): 624-630. (in Chinese)
张弛, 胡舒铃, 孙鹏, 等. 大学教师胆结石患病现状及危险因素的多中心研究[J]. 临床肝胆病杂志, 2020, 36(3): 624-630.

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