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基于数据挖掘分析FAM134B在肝癌中的表达及其与预后的关系
Expression of FAM134B in liver cancer and its association with prognosis: An analysis based on data mining
文章发布日期:2019年09月29日  来源:  作者:钟蓝海,马丹丹,张智勇,等  点击次数:194次  下载次数:37次

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【摘要】: 目的 研究FAM134B在肝癌组织中的表达情况,探讨其表达差异与临床病理特征以及预后生存的关系。方法 挖掘Oncomine、Human Protein Atlas、TCGA和Kaplan Meier-Plotter数据库,分析FAM134B在肝癌组织中的表达,并对表达量与临床病理特征以及预后生存的关系进行探讨。计数资料组间比较采用χ2检验。FAM134B表达与肝癌预后的关系采用Kaplan-Meier模型分析。结果 正常组织中,FAM134B在肾脏中表达量最高,肝脏居第9位,肿瘤组织中,其在肾癌组织表达最高,肝癌第11位。共147项有关FAM134B表达差异的研究结果差异具有统计学意义,各种癌症中其表达差异不一致。其在肝癌组织中表达量较正常肝组织中低。FAM134B蛋白定位于内质网,其表达量与肝癌患者发病年龄、肝硬化、AFP、人种、分化程度有相关性(P值均<0.05)。FAM134B表达量与肝癌患者总生存率有关[风险比(HR)=0.67,95%可信区间(95%CI):0.47~0.95,P=0.026],且对亚洲人种预后有显著影响(HR=0.40,95%CI:0.22~0.74,P=0.003),但对白色人种影响不显著(HR=0.65,95%CI:0.40~1.05,P=0.076)。结论 FAM134B在不同癌症中表达不一致,在肝癌中低表达,蛋白定位于内质网,其低表达与肝癌部分恶性表型相关,且与患者总体生存率低有关。
【Abstract】: Objective To investigate the expression of FAM134B in liver cancer and its association with clinicopathological features and prognosis. Methods Data mining was performed for Oncomine, Human Protein Atlas, TCGA, and Kaplan Meier-Plotter databases to analyze the expression of FAM134B in liver cancer, and the association of the expression of FAM134B with clinicopathological characteristics and prognosis was analyzed. The chi-square test was used for comparison of categorical data between groups, and the Kaplan-Meier method was used to investigate the association between FAM134B expression and prognosis of liver cancer. Results As for normal tissue, the highest expression level of FAM134B was found in the kidney, and the expression of FAM134B in the liver ranked 9th; as for tumor tissue, the highest expression of FAM134B was found in renal cancer, and the expression of FAM134B in liver cancer ranked 11th. A total of 147 studies found a significant difference in FAM134B expression, and there was a significant difference in FAM134B expression between various tumors. FAM134B expression in liver cancer tissue was lower than that in normal liver tissue. FAM134B protein was localized in the endoplasmic reticulum, and its expression was associated with age of onset of liver cancer patients, liver cirrhosis, alpha-fetoprotein, race, and degree of tumor differentiation (all P<0.05). FAM134B expression was associated with the overall survival rate of liver cancer patients (hazard ratio [HR]=0.67, 95% confidence interval [CI]: 0.47-0.95, P=0.026) and had significant influence on the prognosis of the Asian population (HR=0.40, 95%CI: 0.22-0.74, P=0.003), while it had no significant influence on the prognosis of the Caucasian population (HR=0.65, 95%CI: 0.40-1.05, P=0.076). Conclusion There is a significant difference in the expression of FAM134B between tumors, with a low expression in liver cancer. FAM134B protein is localized in the endoplasmic reticulum, and its low expression is associated with several malignant phenotypes of liver cancer and the low overall survival rate.
【关键字】:肝肿瘤; 数据挖掘; FAM134B; 预后
【Key words】:liver neoplasms; data mining; family with sequence similarity 96, member B; prognosis
【引证本文】:ZHONG LH, MA DD, ZHANG ZY, et al. Expression of FAM134B in liver cancer and its association with prognosis: An analysis based on data mining[J]. J Clin Hepatol, 2019, 35(11): 2508-2512. (in Chinese)
钟蓝海, 马丹丹, 张智勇, 等. 基于数据挖掘分析FAM134B在肝癌中的表达及其与预后生存的关系[J]. 临床肝胆病杂志, 2019, 35(11): 2508-2512.

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