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长链非编码RNA在胆管癌发生发展中的作用
Role of long non-coding RNA in the development and progression of cholangiocarcinoma
文章发布日期:2019年08月20日  来源:  作者:张世龙,高伟东,冯赞杰,等  点击次数:307次  下载次数:95次

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【摘要】:胆管癌是起源于胆管上皮细胞的恶性肿瘤,发病率及病死率呈逐年上升趋势,其机制不清使该病早期诊疗困难。随着基因工程学与生物信息学的发展,越来越多的研究发现长链非编码RNA(lncRNA)与胆管癌的病理生理过程密切相关。归纳了近年lncRNA在胆管癌中介导细胞增殖、凋亡、转移、侵袭、上皮-间质转化、耐药等生物学行为及临床特征和预后关系的研究成果。
【Abstract】:Cholangiocarcinoma is a malignant tumor originating from the epithelial cells of the bile duct, and its incidence and mortality rates keep increasing year by year. Unknown pathogenesis of this disease has led to the difficulties in early diagnosis and treatment. With the development of genetic engineering and bioinformatics, more and more studies have found that long non-coding RNA (lncRNA) is closely associated with the pathophysiological process of cholangiocarcinoma. This article summarizes the research advances in the role of lncRNA in mediating the biological behaviors of cell proliferation, apoptosis, metastasis, invasion, epithelial-mesenchymal transition, and drug resistance in cholangiocarcinoma, as well as the association of lncRNA with clinical features and prognosis.
【关键字】:胆管肿瘤; RNA, 长链非编码; 病理过程
【Key words】:bile duct neoplasms; RNA, long noncoding; pathologic processes
【引证本文】:ZHANG SL, GAO WD, FENG ZJ, et al. Role of long non-coding RNA in the development and progression of cholangiocarcinoma[J]. J Clin Hepatol, 2019, 35(8): 1885-1888. (in Chinese)
张世龙, 高伟东, 冯赞杰, 等. 长链非编码RNA在胆管癌发生发展中的作用[J]. 临床肝胆病杂志, 2019, 35(8): 1885-1888.

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