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肝硬化患者血清血小板生成素水平的测定及临床意义
Detect on serum thrombopoietin levels in patients with liver cirrhosis and it's clinic significance
文章发布日期:2009年10月10日  来源:  作者:周建尧; 单平囡; 王玲子; 冯幼菊; 杨金荣; 孔园珍; 丁修民; 宣国红   点击次数:1516次  下载次数:653次

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【摘要】:探讨肝硬化患者血清血小板生成素(TOP)浓度与血小板减少的关系。用酶联免疫吸附法(ELISA)测定肝硬化肝功能代偿期、失代偿期以及正常人血清TPO浓度。血清TOP浓度正常人、肝硬化肝功能代偿期、失代偿期分别为(136.24±68.56)pg.m l-1、(124.34±41.31)pg.m l-1和(59.05±52.77)pg.m l-1。肝硬化肝功能失代偿期的血清TPO浓度较正常人明显降低(t=4.04,P<0.001);正常人的血清TPO浓度受外周血小板计数的调节,而肝硬化患者的血清TPO浓度与外周血小板计数之间无明显相关而与血清白蛋白浓度呈正相关(r=0.86,P<0.001)、血清总胆红素浓度呈负相关(r=0.49,P<0.05)。肝细胞产生TPO不足可能是肝硬化发生血小板减少的主要原因。血清TPO浓度可能是评价肝硬化患者肝功能的有用指标。
【Abstract】:To observe the relationship on serum thrombopoietin(TPO) levels and thrombocytopenia in patients with liver cirrhosis and it's significance in liver function evaluation.Serum TPO levels in patients with liver cirrhosis(liver function compensative or decompensative) and normal controls were detected by ELISA.The serum TPO levels of normal controls,patients with compensative liver function and patients with decompensative liver function were(136.24±68.56) pg·ml-1,(124.34±41.31)pg·ml-1 and(59.05±52.77)pg·ml-1 respectively.The TPO level of patients with decompensative liver function was significantly lower than that of normal controls(t=4.04,P<0.001).In the patients with liver cirrhosis,the serum TPO level was correlated with serum concentration of album(r=0.86,P<0.001) and negative correlated with serum concentration of tatol bilirubin(r=-0.49,P<0.05).Insufficient of TPO production in liver maybe the main cause of thrombocytopenia in the patients with liver cirrhosis.The
【关键字】:肝硬化; 血小板生成素; 血小板减少
【Key words】:liver cirrhosis; thrombopoietin; thrombocytopenia
【引证本文】:

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