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Treg/Th17、Th1/Th2平衡在自身免疫性肝炎中的免疫学机制及诊疗新靶点
Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment
文章发布日期:2019年07月05日  来源:  作者:王维钊,向晓星  点击次数:380次  下载次数:70次

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【摘要】:自身免疫性肝炎(AIH) 是一种发生在肝脏的慢性自身免疫性疾病,临床主要表现为自身抗体阳性,转氨酶异常升高,高丙种球蛋白血症。目前的研究显示,调节性T淋巴细胞(Treg)/辅助性T淋巴细胞(Th)17、Th1/Th2失衡是AIH发生发展机制之一。而OX40与其配体OX40L是肿瘤坏死因子家族的成员,二者结合作为T淋巴细胞活化的协同性刺激因子参与免疫应答,能够调节Treg/Th17、Th1/Th2平衡,影响多种自身免疫性疾病进程。但目前其在AIH的研究鲜有报道。查阅相关文献,围绕Treg/Th17、Th1/Th2平衡在AIH中的作用及免疫诊疗新靶点OX40/OX40L与AIH的潜在关系作一综述。
【Abstract】:Autoimmune hepatitis (AIH) is a chronic autoimmune disease in the liver, with major clinical manifestations of positive autoantibody, abnormal elevation of aminotransferases, and hypergammaglobulinemia. Current studies have shown that regulatory T (Treg)/T helper 17 (Th17) and T helper 1 (Th1)/T helper 2 (Th2) imbalance is one of the mechanisms of the development and progression of AIH. OX40 (also known as CD134, TNFRSF4, or ACT35) and its ligand OX40L are members of the tumor necrosis factor family, and they participate in immune response as co-stimulators of T cell activation and can regulate Treg/Th17 and Th1/Th2 balance, thus affecting the progression of various autoimmune diseases. However, there are few reports on the role of OX40 and OX40L in AIH. With reference to related articles, this article reviews the role of Treg/Th17 and Th1/Th2 balance in AIH and the potential association between OX40/OX40L (new targets for immunological diagnosis and treatment) and AIH.
【关键字】:肝炎, 自身免疫性; T淋巴细胞, 调节性; T淋巴细胞, 辅助诱导
【Key words】:hepatitis, autoimmune; T-lymphocytes, regulatory; T-lymphocytes, helper-inducers
【引证本文】:WANG WZ, XIANG XX. Immunological mechanism of Treg/Th17 and Th1/Th2 balance in autoimmune hepatitis and new targets for diagnosis and treatment[J]. J Clin Hepatol, 2019, 35(8): 1874-1877. (in Chinese)
王维钊, 向晓星. Treg/Th17、Th1/Th2平衡在自身免疫性肝炎中的免疫学机制及诊疗新靶点[J]. 临床肝胆病杂志, 2019, 35(8): 1874-1877.

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