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肝硬化患者肠道屏障与细菌易位的关系
Association between intestinal barrier and bacterial translocation in patients with liver cirrhosis
文章发布日期:2019年07月05日  来源:  作者:李佩波,秦凡博,龚建平  点击次数:301次  下载次数:80次

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【摘要】:失代偿期肝硬化常并发多种威胁生命的并发症,如自发性细菌性腹膜炎、肝性脑病、脓毒症等,而肝硬化并发症的发生与细菌易位有着密切的关系。肝硬化患者发生病理性细菌易位的原因在于肠道屏障功能受损,导致细菌能够穿越肠道屏障进入肠系膜淋巴结或其他部位。因此,更好地理解肝硬化时肠道屏障与细菌易位的关系,将会为肝硬化的治疗提供新的理论支持。主要讨论了肠道屏障的4个主要构成成份,即肠道的机械屏障、免疫屏障、化学屏障、生物屏障,以及它们各自在肝硬化细菌易位时发生的变化。
【Abstract】:Decompensated liver cirrhosis has various life-threatening complications such as spontaneous bacterial peritonitis, hepatic encephalopathy, and sepsis, and the development of such complications is closely associated with bacterial translocation. Pathological bacterial translocation in patients with liver cirrhosis is caused by the impairment of intestinal barrier function, and thus bacteria can cross the intestinal barrier and enter the mesenteric lymph nodes or other sites. Therefore, a better understanding of the association between intestinal barrier and bacterial translocation in liver cirrhosis can provide new theoretical support for the treatment of liver cirrhosis. This article discusses the four major components of the intestinal barrier, namely the mechanical barrier, the immune barrier, the chemical barrier, and the biological barrier, as well as their changes during bacterial translocation.
【关键字】:肝硬化; 细菌移位; 胃肠道微生物组
【Key words】:liver cirrhosis; bacterial translocation; gastrointestinal microbiome
【引证本文】:LI PB, QIN FB, GONG JP. Association between intestinal barrier and bacterial translocation in patients with liver cirrhosis[J]. J Clin Hepatol, 2019, 35(8): 1854-1857. (in Chinese)
李佩波, 秦凡博, 龚建平. 肝硬化患者肠道屏障与细菌易位的关系[J]. 临床肝胆病杂志, 2019, 35(8): 1854-1857.

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