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慢性HBV感染免疫耐受期诊治进展
Research advances in the diagnosis and treatment of patients in the immune tolerance stage of chronic hepatitis B virus infection
文章发布日期:2019年07月05日  来源:  作者:周路路,刘娜,李春霞,等  点击次数:333次  下载次数:80次

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【摘要】:慢性HBV感染免疫耐受期的患者病毒复制活跃而肝脏处于低炎症状态,一般无疾病进展,因此各大指南不推荐抗病毒治疗。近期有研究发现免疫耐受期患者体内存在免疫应答,肝脏伴有损伤且是肝癌发生的危险因素,建议积极启动抗病毒治疗以阻止疾病进展。对目前慢性HBV感染免疫耐受期的诊治进展进行了总结,该期患者是否给予抗病毒治疗是一个极具争议性的话题,把握合适的治疗时机对改善患者预后、减轻其经济负担具有重要意义。
【Abstract】:Patients in the immune tolerance stage of chronic hepatitis B virus (HBV) infection are in a state of high viral replication and low inflammation in the liver, and they often have no disease progression. Therefore, antiviral therapy is not recommended in related guidelines. Recent studies have found that the patients in the immune tolerance stage have immune response and liver injury, which is a risk factor for liver cancer, and therefore, antiviral therapy should be actively initiated to prevent disease progression. This article summarizes the research advances in the diagnosis and treatment of patients in the immune tolerance stage of chronic HBV infection and points out that there are still controversies over the application of antiviral therapy in such patients. Appropriate timing of antiviral therapy has a great significance in improving patients’ prognosis and reducing their economic burden.
【关键字】:乙型肝炎病毒; 免疫耐受; 诊断; 治疗学
【Key words】:hepatitis B virus; immune tolerance; diagnosis; therapeutics
【引证本文】:ZHOU LL, LIU N, LI CX, et al. Research advances in the diagnosis and treatment of patients in the immune tolerance stage of chronic hepatitis B virus infection[J]. J Clin Hepatol, 2019, 35(8): 1824-1827. (in Chinese)
周路路, 刘娜, 李春霞, 等. 慢性HBV感染免疫耐受期诊治进展[J]. 临床肝胆病杂志, 2019, 35(8): 1824-1827.

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