首 页   本刊简介  编委会  审稿专家  在线期刊  写作规范  广告合作  联系我们
您现在的位置:首页 => 在线期刊 => 2019年 7期 妊娠期肝病的个体化精准诊疗 => 病毒性肝炎 =>陕西地区孕妇HBV感..
陕西地区孕妇HBV感染现状与母婴传播的危险因素
Current status of hepatitis B virus infection among pregnant women in Shaanxi Province, China and risk factors for mother-to-infant transmission
文章发布日期:2019年06月14日  来源:  作者:余强,王静,刘锦锋,等  点击次数:248次  下载次数:60次

调整字体大小:

(此处下载失败可以在在线预览处保存副本或者右键另存为)

【摘要】:目的调查陕西省孕妇HBV感染率并筛选母婴传播高危人群。方法自2010年-2015年连续调查了陕西省18家医院13 451名孕妇HBV感染情况,对所有HBsAg阳性孕妇所生婴儿进行联合免疫,采用单因素及多因素logistic回归分析母婴传播的高危因素。计量资料组间比较采用t检验或Mann-Whitney U检验。计数资料多组间比较采用χ2检验。结果陕西省孕妇HBsAg流行率为7.07%,陕南地区高达9.40%。HBV母婴传播率为5.21%,单因素分析显示母亲HBsAg滴度、HBeAg滴度、HBeAg阳性及HBV DNA载量与婴儿HBV感染相关,多因素分析显示母亲HBV DNA载量是母婴传播的独立危险因素(相对危险度:1.586,95%可信区间:1.020~2.465,P=0.041)。发生母婴传播的HBV感染孕妇中,84.62%为HBeAg阳性且HBV DNA>106 IU/ml;发生母婴传播的婴儿15.38%来自于HBeAg阴性的HBV感染孕妇。HBeAg阳性且HBV DNA>106 IU/ml的孕妇中,婴儿发生母婴传播的相对危险度为1.210(1.129~1.297);而HBeAg阴性,但HBV DNA>2×103 IU/ml且HBsAg>104 IU/ml的孕妇中,婴儿发生母婴传播的相对危险度为26.062(2.633~258.024)。结论陕西省孕妇HBV感染率仍高,HBeAg阳性且高病毒载量孕妇发生母婴传播风险较高;HBeAg阴性母亲所生婴儿HBV感染率虽然低,但当母亲HBV DNA>2×103 IU/ml且HBsAg>104 IU/ml时仍有较高母婴传播的风险。
【Abstract】:ObjectiveTo investigate the hepatitis B virus (HBV) infection rate among pregnant women in Shaanxi Province, China and the high-risk population of mother-to-infant transmission (MTIT). MethodsA survey was performed for 13 451 pregnant women in 18 hospitals in Shaanxi Province to investigate the status of HBV infection, and combined immunization was performed for the infants born to HBsAg-positive women. Univariate and multivariate logistic regression analyses were used to investigate the risk factors for MTIT. The t-test or the Mann-Whitney U test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. ResultsThe prevalence rate of HBsAg was 7.07% among the pregnant women in Shaanxi Province, and the rate reached as high as 9.40% in southern Shaanxi. The MTIT rate of HBV was 5.21%. The univariate analysis showed that HBsAg titer, HBeAg titer, positive HBeAg, and HBV DNA load in mothers were associated with HBV infection in infants, and the multivariate analysis showed that HBV DNA load in mothers is an independent risk factor for MTIT (relative risk=1.586, 95% confidence interval: 1.020-2.465, P=0.041). Among the pregnant women with HBV infection and MTIT, 84.62% had positive HBeAg and an HBV DNA load of >106 IU/ml; among the infants with MTIT, 15.38% were the infants born to the HBeAg-negative pregnant women. For the pregnant women with positive HBeAg and HBV DNA>106 IU/ml, the relative risk of MTIT in infants was 1.210 (1.129-1.297); for the pregnant women with negative HBeAg, HBV DNA>2×103 IU/ml, and HBsAg >104 IU/ml, the relative risk of MTIT in infants was 26.062 (2.633-258024). ConclusionThere is a high HBV infection rate among pregnant women in Shaanxi Province. Pregnant women with positive HBeAg and a high HBV DNA load have a high risk of MTIT. Although the infants born to HBeAg-negative mothers have a low HBV infection rate, there is still a high risk of MTIT when the mother has an HBV DNA load of >2×103 IU/ml and an HBsAg level of >104 IU/ml.
【关键字】:乙型肝炎病毒;乙型肝炎表面抗原;母婴传播;妊娠;孕妇
【Key words】:hepatitis B virus; hepatitis B surface antigens; mother-to-infant transmission; pregnancy; pregnant women
【引证本文】:YU Q, WANG J, LIU JF, et al. Current status of hepatitis B virus infection among pregnant women in Shaanxi Province, China and risk factors for mother-to-infant transmission[J]. J Clin Hepatol, 2019, 35(7): 1489-1492. (in Chinese)
余强, 王静, 刘锦锋, 等. 陕西地区孕妇HBV感染现状与母婴传播的危险因素[J]. 临床肝胆病杂志, 2019, 35(7): 1489-1492.

地址:长春市东民主大街519号《临床肝胆病杂志》编辑部 邮编:130061 电话:0431-88782542/3542
临床肝胆病杂志 版权所有 Copyright © 2009 - 2013 Lcgdbzz.org. All Rights Reserv 吉ICP备10000617号

吉公网安备 22010402000041号