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胆汁淤积性肝病相关基因及其在妊娠期肝内胆汁淤积症中的作用
Role of cholestatic liver disease-related genes in intrahepatic cholestasis of pregnancy
文章发布日期:2019年06月14日  来源:  作者:阚延婷,杨永峰  点击次数:253次  下载次数:145次

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【摘要】:妊娠期肝内胆汁淤积症(ICP)是妊娠期最常见的特异性肝病。通常出现在妊娠晚期,主要表现为皮肤瘙痒、黄疸,实验室检查血清总胆汁酸及转氨酶升高,对胎儿影响较大,可导致早产、死胎、畸形。其病因复杂,研究发现遗传、代谢、免疫、激素等多种因素均可导致其发病。与胆汁淤积相关的基因,如ABCB11、ABCB4、ATP8B1、FXR等与ICP的遗传易感性有关。综述了胆汁淤积相关基因及其与ICP的关系。
【Abstract】:Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease during pregnancy. ICP usually occurs in late pregnancy, with main manifestations of pruritus, jaundice, and increases in serum levels of total bile acid and aminotransferases found by laboratory examination. ICP has great impact on the fetus and may lead to preterm birth, stillbirth, and deformity. ICP has complex etiologies, and studies have shown that genetic, metabolic, immunological, and hormonal factors may contribute to the onset of ICP. The genes associated with cholestasis, such as ABCB11, ABCB4, ATP8B1, and FXR, are associated with the genetic susceptibility of ICP. This article reviews the association between cholestasis-related genes and ICP.
【关键字】:胆汁淤积;妊娠并发症;基因;遗传变异
【Key words】:cholestasis; pregnancy complications; genes; genetic variation
【引证本文】:KAN YT, YANG YF. Role of cholestatic liver disease-related genes in intrahepatic cholestasis of pregnancy[J]. J Clin Hepatol, 2019, 35(7): 1439-1443. (in Chinese)
阚延婷,杨永峰. 胆汁淤积性肝病相关基因及其在妊娠期肝内胆汁淤积症中的作用[J]. 临床肝胆病杂志, 2019, 35(7): 1439-1443.

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