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妊娠对慢性HBV感染自然史的影响
Influence of pregnancy on the natural history of chronic hepatitis B virus infection
文章发布日期:2019年06月14日  来源:  作者:陈雨欣,黄睿,吴超  点击次数:249次  下载次数:133次

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【摘要】:慢性HBV感染依然是我国严重的公共卫生问题,其中我国孕妇HBsAg携带率高达6.0%~7.8%。妊娠期间,母体免疫系统处于抑制状态,进而可能会影响HBV感染的自然史。目前,妊娠对HBV感染自然史的影响尚无定论。从妊娠期内母体的免疫抑制现象和妊娠对慢性HBV感染者体内病毒复制、HBeAg血清学转换、肝功能及肝脏疾病进程的影响等方面,综述了妊娠对慢性HBV感染自然史的影响相关的研究进展,并建议临床应当密切监测慢性HBV感染的孕妇在妊娠期和产后的病毒学和肝功能实验室检查。
【Abstract】:Chronic hepatitis B virus (HBV) infection is still a serious public health problem in China, and the HBsAg carrying rate reaches 6.0%-7.8% in pregnant women. Maternal immune system is suppressed during pregnancy, which may affect the natural history of HBV infection. At present, no consensus has been reached on the influence of pregnancy on the natural history of HBV infection. The article reviews the research advances in the influence of pregnancy on the natural history of HBV infection from the aspects of maternal immunosuppression during pregnancy and the effect of pregnancy on viral replication, HBeAg seroconversion, liver function, and liver disease progression. Pregnant women with chronic HBV infection should be closely monitored in clinical practice in terms of virological examination and liver function examination during pregnancy and postpartum.
【关键字】:乙型肝炎病毒;妊娠; 治疗学;孕妇
【Key words】:hepatitis B virus;pregnancy; therapeutics; pregnant women
【引证本文】:CHEN YX, HUANG R, WU C. Influence of pregnancy on the natural history of chronic hepatitis B virus infection[J]. J Clin Hepatol, 2019, 35(7): 1430-1434. (in Chinese)
陈雨欣,黄睿,吴超. 妊娠对慢性HBV感染自然史的影响[J]. 临床肝胆病杂志, 2019, 35(7) 1430-1434.

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