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CN 22-1108/R
Issue 7
Jul.  2012
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Role of “two-hit” in non-alcoholic fatty liver disease

  • Published Date: 2012-07-20
  • The manifestation of non-alcoholic fatty liver disease (NAFLD) ranges from simple steatosis to non-alcoholic steatohepatitis.The "two-hit" hypothesis of NAFLD is widely accepted as an accurate description of the underlying pathogenic mechanism.The first hit is an increased fat flux to the liver, which predisposes a patient to the second hit, in which increased mitochondrial free fatty acid oxidation promotes oxidative stress, lipoperoxidation, and increased reactive oxygen species.In this review, we discuss the roles of immune-and inflammation-related factors, such as cytokines, and metabolic factors in the "two-hit" process of NAFLD.


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