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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 38 Issue 6
Jun.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(6): 1440-1444

Indoleamine 2, 3-dioxygenase: An important medium with the role of a double-edged sword in various liver diseases

DOI: 10.3969/j.issn.1001-5256.2022.06.046
  • 1.

    Graduate School of Qinghai University, Xining 810016, China

  • 2.

    Department of Hepatopancre-atobiliary Surgery, The Affiliated Hospital of Qinghai University, Xining 810001, China

  • 3.

    Qinghai Academy of Animal Husbandry and Veterinary Sciences, Xining 810016, China

Research funding:

National Natural Science Foundation of China (31960708);

Applied Basic Research of Qinghai Province (2021-ZJ-724)

More Information
  • Corresponding author: WANG Hongbin, 13897649826@163.com(ORCID: 0000-0002-8865-3238); FU Yong, qhfuyong@163.com(ORCID: 0000-0003-3354-9107)
  • Received Date: 2021-10-15
  • Accepted Date: 2021-11-17
  • Published Date: 2022-06-20
    Abstract
  • Indoleamine 2, 3-dioxygenase (IDO) is an important immunoregulatory enzyme, which can degrade the level of the mammalian essential amino acid tryptophan (TRP), catalyze the initiation and rate-limiting steps through the kynurenine pathway, and produce a variety of metabolites to participate in the immune response. On the one hand, IDO plays an immunosuppressive role in microenvironment and thus leads to infection and immune escape of tumor cells; on the other hand, IDO also exerts an inhibitory effect on the pathogens such as bacteria and parasites and thus protects the body from the harm of pathogens to a certain extent. Therefore, IDO is considered an important medium with the role of a double-edged sword in the development and progression of various liver diseases. This article reviews the latest research advances in IDO in viral hepatitis, liver fibrosis, liver cirrhosis, liver cancer, and hepatic echinococcosis.

     

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