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Volume 38 Issue 6
Jun.  2022
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Article Navigation >  Journal of Clinical Hepatology  > 2022  >  38(6): 1393-1397

Association of signal transducer and activator of transcription 3 and signal transducer and activator of transcription 5 with regulatory T cell/T helper 17 cell balance in chronic hepatitis B

DOI: 10.3969/j.issn.1001-5256.2022.06.036
  • 1.

    NHC Key Laboratory of Drug Addiction Medicine, Department of Geriatric Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

  • 2.

    School of Public Health, Kunming Medical University, Kunming 650500, China

More Information
  • Corresponding author: YOU Jing, jingyoukm@126.com(ORCID: 0000-0002-5919-5864)
  • Received Date: 2021-09-26
  • Accepted Date: 2021-11-02
  • Published Date: 2022-06-20
    Abstract
  • The immune mechanism of chronic hepatitis B (CHB) persistent infection is closely associated with T cells, and the development of T cells requires the coordination of a variety of cytokines. The proteins of the signal transducer and activator of transcription (STAT) family are mainly involved in the signal transduction of cytokines, and STAT5a/b and STAT3 play an important role in the differentiation and development of regulatory T cells (Treg) and T helper 17 cells (Th17). This article analyzes the association of STAT3 and STAT5 with Treg/Th17 balance in CHB and investigates the chronicity of hepatitis B virus infection and the regulatory mechanism of liver inflammation.

     

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