中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 12
Dec.  2021
Turn off MathJax
Article Contents

Research advances in active components of traditional Chinese medicine in prevention and treatment of nonalcoholic fatty liver disease based on oxidative stress

DOI: 10.3969/j.issn.1001-5256.2021.12.046
Research funding:

Special projects for the central government to guide the development of local science and technology (ZYYD2020000147)

  • Received Date: 2021-05-06
  • Accepted Date: 2021-06-21
  • Published Date: 2021-12-20
  • Nonalcoholic fatty liver disease (NAFLD) is a multifactorial pathological disease. Although the molecular mechanism of the onset of NAFLD has not been fully elucidated, oxidative stress is believed to play a key role in this process and can affect a variety of physiological functions. In recent years, the use of active components of traditional Chinese medicine in the prevention and treatment of NAFLD has become a research hotspot. This article summarizes the role of active components of traditional Chinese medicine in the treatment of NAFLD from the perspective of anti-oxidative stress effect, so as to provide a scientific basis for the prevention and treatment of NAFLD.

     

  • loading
  • [1]
    STEFAN N, HÄRING HU, CUSI K. Non-alcoholic fatty liver disease: Causes, diagnosis, cardiometabolic consequences, and treatment strategies[J]. Lancet Diabetes Endocrinol, 2019, 7(4): 313-324. DOI: 10.1016/S2213-8587(18)30154-2.
    [2]
    ESTES C, ANSTEE QM, ARIAS-LOSTE MT, et al. Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030[J]. J Hepatol, 2018, 69(4): 896-904. DOI: 10.1016/j.jhep.2018.05.036.
    [3]
    TU W, WANG H, LI S, et al. The anti-inflammatory and anti-oxidant mechanisms of the Keap1/Nrf2/ARE signaling pathway in chronic diseases[J]. Aging Dis, 2019, 10(3): 637-651. DOI: 10.14336/AD.2018.0513.
    [4]
    PAN X, WEN SW, KAMINGA AC, et al. Gut metabolites and inflammation factors in non-alcoholic fatty liver disease: A systematic review and meta-analysis[J]. Sci Rep, 2020, 10(1): 8848. DOI: 10.1038/s41598-020-65051-8.
    [5]
    QIAN SJ, GU JY, GAO JH, et al. Advances in therapeutic drugs for nonalcoholic steatohepatitis[J]. J Clin Hepatol, 2020, 36(12): 2826-2830. DOI: 10.3969/j.issn.1001-5256.2020.12.039.

    钱帅杰, 谷劲岳, 高锦航, 等. 非酒精性脂肪性肝炎治疗药物的进展[J]. 临床肝胆病杂志, 2020, 36(12): 2826-2830. DOI: 10.3969/j.issn.1001-5256.2020.12.039.
    [6]
    QIAN K, LIU YY, ZHANG Y, et al. Research progress on molecular mechanism of traditional Chinese medicine against non-alcoholic fatty liver disease[J]. Chin Tradit Herbal Drugs, 2020, 51(19): 5083-5092. DOI: 10.7501/j.issn.0253-2670.2020.19.029.

    钱坤, 刘亚云, 张艳, 等. 中药抗非酒精性脂肪肝病分子机制的研究进展[J]. 中草药, 2020, 51(19): 5083-5092. DOI: 10.7501/j.issn.0253-2670.2020.19.029.
    [7]
    SIMÖES I, FONTES A, PINTON P, et al. Mitochondria in non-alcoholic fatty liver disease[J]. Int J Biochem Cell Biol, 2018, 95: 93-99. DOI: 10.1016/j.biocel.2017.12.019.
    [8]
    ALJOMAH G, BAKER SS, LIU W, et al. Induction of CYP2E1 in non-alcoholic fatty liver diseases[J]. Exp Mol Pathol, 2015, 99(3): 677-681. DOI: 10.1016/j.yexmp.2015.11.008.
    [9]
    MASARONE M, ROSATO V, DALLIO M, et al. Corrigendum to "role of oxidative stress in pathophysiology of nonalcoholic fatty liver disease"[J]. Oxid Med Cell Longev, 2021, 2021: 9757921. DOI: 10.1155/2021/9757921.
    [10]
    JIANG JX, TÖRÖK NJ. NADPH oxidases in chronic liver diseases[J]. Adv Hepatol, 2014, 2014: 742931. DOI: 10.1155/2014/742931.
    [11]
    DATZ C, MVLLER E, AIGNER E. Iron overload and non-alcoholic fatty liver disease[J]. Minerva Endocrinol, 2017, 42(2): 173-183. DOI: 10.23736/S0391-1977.16.02565-7.
    [12]
    GRATTAGLIANO I, de BARI O, BERNARDO TC, et al. Role of mitochondria in nonalcoholic fatty liver disease-from origin to propagation[J]. Clin Biochem, 2012, 45(9): 610-618. DOI: 10.1016/j.clinbiochem.2012.03.024.
    [13]
    SIMÖES I, FONTES A, PINTON P, et al. Mitochondria in non-alcoholic fatty liver disease[J]. Int J Biochem Cell Biol, 2018, 95: 93-99. DOI: 10.1016/j.biocel.2017.12.019.
    [14]
    KOEK GH, LIEDORP PR, BAST A. The role of oxidative stress in non-alcoholic steatohepatitis[J]. Clin Chim Acta, 2011, 412(15-16): 1297-1305. DOI: 10.1016/j.cca.2011.04.013.
    [15]
    GAO D, WEI C, CHEN L, et al. Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease[J]. Am J Physiol Gastrointest Liver Physiol, 2004, 287(5): G1070-G1077. DOI: 10.1152/ajpgi.00228.2004.
    [16]
    SPAHIS S, DELVIN E, BORYS JM, et al. Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis[J]. Antioxid Redox Signal, 2017, 26(10): 519-541. DOI: 10.1089/ars.2016.6776.
    [17]
    CORREIA MA, KWON D. Why hepatic CYP2E1-elevation by itself is insufficient for inciting NAFLD/NASH: Inferences from two genetic knockout mouse models[J]. Biology (Basel), 2020, 9(12). DOI: 10.3390/biology9120419.
    [18]
    AUBERT J, BEGRICHE K, KNOCKAERT L, et al. Increased expression of cytochrome P450 2E1 in nonalcoholic fatty liver disease: Mechanisms and pathophysiological role[J]. Clin Res Hepatol Gastroenterol, 2011, 35(10): 630-637. DOI: 10.1016/j.clinre.2011.04.015.
    [19]
    DIESINGER T, LAUTWEIN A, BUKO V, et al. ω-Imidazolyl-alkyl derivatives as new preclinical drug candidates for treating non-alcoholic steatohepatitis[J]. Physiol Rep, 2021, 9(6): e14795. DOI: 10.14814/phy2.14795.
    [20]
    LEBEAUPIN C, VALLÉE D, HAZARI Y, et al. Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease[J]. J Hepatol, 2018, 69(4): 927-947. DOI: 10.1016/j.jhep.2018.06.008.
    [21]
    MASARONE M, ROSATO V, DALLIO M, et al. Role of oxidative stress in pathophysiology of nonalcoholic fatty liver disease[J]. Oxid Med Cell Longev, 2018, 2018: 1-14. DOI: 10.1155/2018/9547613
    [22]
    WEI Y, WANG D, GENTILE C L, et al. Reduced endoplasmic reticulum luminal calcium links saturated fatty acid-mediated endoplasmic reticulum stress and cell death in liver cells[J]. Mol Cell Biochem, 2009, 331(1-2): 31-40. DOI: 10.1007/s11010-009-0142-1.
    [23]
    XU H, TIAN Y, TANG D, et al. An Endoplasmic reticulum stress-microRNA-26a feedback circuit in NAFLD[J]. Hepatology, 2021, 73(4): 1327-1345. DOI: 10.1002/hep.31428.
    [24]
    LOFFREDO L, DEL BEN M, PERRI L, et al. Effects of dark chocolate on NOX-2-generated oxidative stress in patients with non-alcoholic steatohepatitis[J]. Aliment Pharmacol Ther, 2016, 44(3): 279-286. DOI: 10.1111/apt.13687.
    [25]
    NELSON JE, KLINTWORTH H, KOWDLEY KV. Iron metabolism in nonalcoholic fatty liver disease[J]. Curr Gastroenterol Rep, 2012, 14(1): 8-16. DOI: 10.1007/s11894-011-0234-4.
    [26]
    EDER SK, FELDMAN A, STREBINGER G, et al. Mesenchymal iron deposition is associated with adverse long-term outcome in non-alcoholic fatty liver disease[J]. Liver Int, 2020, 40(8): 1872-1882. DOI: 10.1111/liv.14503.
    [27]
    ZHONG X, LIU H. Baicalin attenuates diet induced nonalcoholic steatohepatitis by inhibiting inflammation and oxidative stress via suppressing JNK signaling pathways[J]. Biomed Pharmacother, 2018, 98: 111-117. DOI: 10.1016/j.biopha.2017.12.026.
    [28]
    OU Q, WENG Y, WANG S, et al. Silybin alleviates hepatic steatosis and fibrosis in NASH mice by inhibiting oxidative stress and involvement with the Nf-κB pathway[J]. Dig Dis Sci, 2018, 63(12): 3398-3408. DOI: 10.1007/s10620-018-5268-0.
    [29]
    LIU JJ, DAI L, DONG L, et al. Effects of polydatin on nonalcoholic fatty liver and related molecular mechanisms[J]. Chin J Immunol, 2019, 35(10): 1188-1192. DOI: 10.3969/j.issn.1000-484X.2019.10.008.

    刘皎皎, 戴玲, 董璐, 等. 虎杖苷对非酒精性脂肪肝的影响及相关分子机制探究[J]. 中国免疫学杂志, 2019, 35(10): 1188-1192. DOI: 10.3969/j.issn.1000-484X.2019.10.008.
    [30]
    PORRAS D, NISTAL E, MARTÍNEZ-FLÓREZ S, et al. Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation[J]. Free Radic Biol Med, 2017, 102: 188-202. DOI: 10.1016/j.freeradbiomed.2016.11.037.
    [31]
    YAUN QF, TANG SM, CHEN SY, et al. Therapeutic effect of astragalus polysaccharides on nonalcoholic fatty liver disease in rats[J]. Acad J Sec Mil Med Univ, 2018, 39(5): 573-578. DOI: 10.16781/j.0258-879x.2018.05.0573.

    袁前发, 唐思梦, 陈思羽, 等. 黄芪多糖对非酒精性脂肪肝病大鼠的治疗作用[J]. 第二军医大学学报, 2018, 39(5): 573-578. DOI: 10.16781/j.0258-879x.2018.05.0573.
    [32]
    SHU T, WANG HR, LI EC, et al. Effects of corn silk polysaccharides on liver miR-146a/NOX4/ROS pathway in rats with non-alcoholic fatty liver[J]. Heilongjiang Med Pharm, 2020, 43(4): 10-12. DOI: 10.3969/j.issn.1008-0104.2020.04.004.

    舒涛, 王浩然, 李恩丞, 等. 玉米须多糖对非酒精性脂肪肝大鼠肝脏miR-146a/NOX4/ROS通路的影响[J]. 黑龙江医药科学, 2020, 43(4): 10-12. DOI: 10.3969/j.issn.1008-0104.2020.04.004.
    [33]
    LI HN, ZHAO LL, ZHOU DY, et al. Ganoderma lucidum polysaccharides ameliorates hepatic steatosis and oxidative stress in db/db mice via targeting nuclear factor E2 (erythroid-derived 2)-related factor-2/heme oxygenase-1 (HO-1) pathway[J]. Med Sci Monit, 2020, 26: e921905. DOI: 10.12659/MSM.921905.
    [34]
    GUO YQ, WU Q, WU YT, et al. Effect of Lycium barbarum polysaccharide and aerobic exercise on rats with non-alcoholic fatty liver disease and its mechanism[J]. J Shanghai Jiaotong Univ(Med Sci), 2020, 40(1): 30-36. DOI: 10.3969/j.issn.1674-8115.2020.01.005.

    郭怡琼, 吴琼, 吴雅婷, 等. 枸杞多糖和有氧运动对大鼠非酒精性脂肪肝的干预效果及其机制研究[J]. 上海交通大学学报(医学版), 2020, 40(1): 30-36. DOI: 10.3969/j.issn.1674-8115.2020.01.005.
    [35]
    GHEIBI S, GOUVARCHIN GHALEH HE, MOTLAGH BM, et al. Therapeutic effects of curcumin and ursodexycholic acid on non-alcoholic fatty liver disease[J]. Biomed Pharmacother, 2019, 115: 108938. DOI: 10.1016/j.biopha.2019.108938.
    [36]
    FENG WW, KUANG SY, TU C, et al. Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin[J]. Biomed Pharmacother, 2018, 99: 325-333. DOI: 10.1016/j.biopha.2018.01.071.
    [37]
    IZDEBSKA M, PI TKOWSKA-CHMIEL I, KOROLCZUK A, et al. The beneficial effects of resveratrol on steatosis and mitochondrial oxidative stress in HepG2 cells[J]. Can J Physiol Pharmacol, 2017, 95(12): 1442-1453. DOI: 10.1139/cjpp-2016-0561.
    [38]
    XIA HM, WANG J, XIE XJ, et al. Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats[J]. Int J Mol Med, 2019, 44(4): 1523-1530. DOI: 10.3892/ijmm.2019.4285.
    [39]
    XU X, ZHU XP, BAI JY, et al. Berberine alleviates nonalcoholic fatty liver induced by a high-fat diet in mice by activating SIRT3[J]. FASEB J, 2019, 33(6): 7289-7300. DOI: 10.1096/fj.201802316R.
    [40]
    DING J, ZHANG B, WEI DM, et al. Effects of berberine hydrochloride on liver oxidative stress and nuclear Nrf2 expression in rats with nonalcoholic fatty liver disease[J]. Immunol J, 2020, 36(3): 201-207. DOI: 10.13431/j.cnki.immunol.j.20200033.

    丁静, 张斌, 魏冬梅, 等. 盐酸小檗碱对非酒精性脂肪肝大鼠肝脏氧化应激水平及Nrf2表达的影响[J]. 免疫学杂志, 2020, 36(3): 201-207. DOI: 10.13431/j.cnki.immunol.j.20200033.
    [41]
    CHEN B, MA Y, XUE X, et al. Tetramethylpyrazine reduces inflammation in the livers of mice fed a high fat diet[J]. Mol Med Rep, 2019, 19(4): 2561-2568. DOI: 10.3892/mmr.2019.9928.
    [42]
    FEI WJ, ZHANG L, DUAN LY, et al. Effect of oxymatrine on lipid accumulation in Hepg2 cells exposed to palmitic acid[J]. J Chongqing Med Univ, 2016, 41(11): 1125-1130. DOI: 10.13406/j.cnki.cyxb.001047.

    费雯婕, 张琳, 段力园, 等. 氧化苦参碱改善棕榈酸诱导的HepG2细胞脂质沉积及氧化应激的研究[J]. 重庆医科大学学报, 2016, 41(11): 1125-1130. DOI: 10.13406/j.cnki.cyxb.001047.
    [43]
    CUI H, LI Y, CAO M, et al. Untargeted metabolomic analysis of the effects and mechanism of nuciferine treatment on rats with nonalcoholic fatty liver disease[J]. Front Pharmacol, 2020, 11: 858. DOI: 10.3389/fphar.2020.00858.
    [44]
    CHENG B, GAO W, WU X, et al. Ginsenoside Rg2 ameliorates high-fat diet-induced metabolic disease through SIRT1[J]. J Agric Food Chem, 2020, 68(14): 4215-4226. DOI: 10.1021/acs.jafc.0c00833.
    [45]
    XU Y, YANG C, ZHANG S, et al. Ginsenoside Rg1 protects against non-alcoholic fatty liver disease by ameliorating lipid peroxidation, endoplasmic reticulum stress, and inflammasome activation[J]. Biol Pharm Bull, 2018, 41(11): 1638-1644. DOI: 10.1248/bpb.b18-00132.
    [46]
    LI GM, LI Y, CHEN L. Ginsenoside Rg1 in the treatment of nonalcoholic fatty liver disease[J]. Chin J Clin Pharmacol Ther, 2020, 25(1): 87-93. DOI: 10.12092/j.issn.1009-2501.2020.01.013.

    李贵明, 李燕, 陈立. 人参皂苷Rg1治疗非酒精性脂肪肝的研究进展[J]. 中国临床药理学与治疗学, 2020, 25(1): 87-93. DOI: 10.12092/j.issn.1009-2501.2020.01.013.
    [47]
    YANG Y, CHEN J, GAO Q, et al. Study on the attenuated effect of Ginkgolide B on ferroptosis in high fat diet induced nonalcoholic fatty liver disease[J]. Toxicology, 2020, 445: 152599. DOI: 10.1016/j.tox.2020.152599.
    [48]
    HAUNG Q, ZHU XQ, WU CM, et al. Effects of asiaticoside on oxidative stress in rats with non-alcoholic fatty liver[J]. Jiangsu J Tradit Chin Med, 2016, 48(3): 81-83. https://www.cnki.com.cn/Article/CJFDTOTAL-JSZY201603037.htm

    黄强, 朱小区, 吴春明, 等. 积雪草苷对非酒精性脂肪肝大鼠氧化应激的影响[J]. 江苏中医药, 2016, 48(3): 81-83. https://www.cnki.com.cn/Article/CJFDTOTAL-JSZY201603037.htm
    [49]
    SHEN B, FENG H, CHENG J, et al. Geniposide alleviates non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signalling pathways[J]. J Cell Mol Med, 2020, 24(9): 5097-5108. DOI: 10.1111/jcmm.15139.
    [50]
    MA Z, CHU L, LIU H, et al. Beneficial effects of paeoniflorin on non-alcoholic fatty liver disease induced by high-fat diet in rats[J]. Sci Rep, 2017, 7: 44819. DOI: 10.1038/srep44819.
    [51]
    XU QM, GAO Y, LI ZM, et al. The effect of gentiopicroside on TLR-4/NF-κB and AMPK/Nrf2 in non-alcoholic fatty liver disease[J]. Nat Prod Res Dev, 2020, 32(10): 1652-1658. DOI: 10.16333/j.1001-6880.2020.10.004.

    许琼梅, 高雅, 李梓萌, 等. 龙胆苦苷对非酒精性脂肪肝TLR-4/NF-κB和AMPK/Nrf2通路的影响[J]. 天然产物研究与开发, 2020, 32(10): 1652-1658. DOI: 10.16333/j.1001-6880.2020.10.004.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(1)

    Article Metrics

    Article views (496) PDF downloads(22) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return