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ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 12
Dec.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(12): 2947-2950

Association between nonalcoholic fatty liver disease and colorectal neoplasms

DOI: 10.3969/j.issn.1001-5256.2021.12.045
  • 1.

    Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China

  • 2.

    Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University; National Clinical Research Center for Digestive Diseases; Beijing Digestive Disease Center; Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, China

Research funding:

National Natural Science Foundation of China (81900505);

Beijing Municipal Administration of Hospitals' Youth Program (QML20200702);

Youth Fund of Beijing Shijitan Hospital (2018-q09)

  • Received Date: 2021-04-22
  • Accepted Date: 2021-06-21
  • Published Date: 2021-12-20
    Abstract
  • Nonalcoholic fatty liver disease (NAFLD) is considered the liver manifestation of metabolic syndrome and is closely associated with the development and progression of colorectal neoplasms. This article reviews the association of NAFLD with colorectal adenoma (CRA) and colorectal cancer (CRC) and possible mechanism, and it is believed that NAFLD promotes the development of CRA and CRC and affects their prognosis, and various factors, such as insulin resistance, adipocytokine, inflammatory response, intestinal flora, and immunity, may be involved in this process.

     

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