Role of exosomes in the development, progression, diagnosis, and treatment of liver fibrosis

Yehao LUO; Qiuxia CHEN; Ting LYU; Peiqi OU; Zhiyong CAO; Xuelin DUAN

doi:10.3969/j.issn.1001-5256.2021.12.038

Volume 37 Issue 12

Dec. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(12): 2919-2923

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Role of exosomes in the development, progression, diagnosis, and treatment of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2021.12.038

1.
Key Laboratory of Zhuang Medicine Prescriptions Basis and Application Research, Guangxi University of Chinese Medicine, Nanning 530200, China
2.
School of Medicine, Hubei Minzu University, Enshi, Hubei 445000, China

Research funding:

University-Level First-Class Discipline Construction Open Subject Project (2019XK040)

Received Date: 2021-04-26
Accepted Date: 2021-06-13
Published Date: 2021-12-20

Abstract

Abstract

An increasing number of studies have demonstrated that exosomes are closely associated with liver fibrosis and mediate the process of liver fibrosis by participating in cytokine secretion, macrophage activation, extracellular matrix remodeling, and hepatic stellate cell activation. This article summarizes that the resolution of liver fibrosis requires the reduction of pro-inflammatory and fibrotic cytokines, the reduction of extracellular matrix protein production, the increase of collagenase activity, and finally the loss of activated myofibroblasts. It is believed that exosomes play an important role in the treatment of liver fibrosis and are potential markers for diagnosis and treatment, and in future studies, it is necessary to improve exosome extraction techniques and standardization of treatment quantification.
- Liver Cirrhosis,
- Exosomes,
- Pathologic Processes,
- Diagnosis,
- Therapeutics

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References(48)

References

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Role of exosomes in the development, progression, diagnosis, and treatment of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2021.12.038

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Role of exosomes in the development, progression, diagnosis, and treatment of liver fibrosis

DOI: 10.3969/j.issn.1001-5256.2021.12.038

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