Role of intestinal flora in metabolic-associated fatty liver disease

Lidan YANG; He HE; Zhenmei AN

doi:10.3969/j.issn.1001-5256.2021.09.046

Volume 37 Issue 9

Sep. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(9): 2231-2235

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Role of intestinal flora in metabolic-associated fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2021.09.046

Lidan YANG^a,
He HE^a,
Zhenmei AN^{b
,
,}

a.
Department of Experimental Medicine, West China Hospital, Sichuan University, Chengdu 610041, China
b.
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China

Research funding:

National Natural Science Foundation of China (32071462);

Science and Technology Department of Sichuan Province (2021YFH0167);

Science and Technology Department of Sichuan Province (2018SZ0382)

Received Date: 2021-01-11
Accepted Date: 2021-02-01
Published Date: 2021-09-20

Abstract

Abstract

In recent years, more and more studies have shown that intestinal flora is critical to the development and progression of metabolic-related fatty liver disease (MAFLD). This article summarizes MAFLD-related intestinal flora and metabolites and their possible mechanisms of action in disease process. Although related intestinal flora and metabolites are expected to become new noninvasive diagnostic markers and therapeutic targets for MAFLD, their clinical application still requires more in-depth research. The development of modern high-throughput sequencing technology provides new ideas for research. The integrated analysis of multi-omics, such as genes, proteins, transcription, and metabolism, allows us to establish a comprehensive understanding of the microbial factors affecting MAFLD under the precision medicine system, so as to lay a foundation for targeted transplantation of intestinal flora and drug development for liver metabolic homeostasis.
- Metabolism-Related Fatty Liver Disease,
- Gastrointestinal Microbiome,
- Metabolism

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References(49)

References

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Role of intestinal flora in metabolic-associated fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2021.09.046

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