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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 9
Sep.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(9): 2171-2176

Effects of FGB gene polymorphism on fibrinogen level and gallstones incidence in Xinjiang, China

DOI: 10.3969/j.issn.1001-5256.2021.09.032
  • a.

    Institute of Minimally Invasive Surgery, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China

  • b.

    Department of Minimally Invasive, Hernia, and Abdominal Wall Surgery, The People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China

Research funding:

Natural Science Foundation of Xinjiang Uygur Autonomous Region (2017D01C096)

  • Received Date: 2021-01-20
  • Accepted Date: 2021-04-01
  • Published Date: 2021-09-20
    Abstract
  •   Objective  To investigate the association of the polymorphisms of the FGB gene rs4220 and rs1044291 loci with plasma fibrinogen (Fg) level and gallstones in Xinjiang, China.  Methods  Blood samples were collected from 150 Uygur and Han patients with gallstones and 150 Uygur and Han individuals without gallstones who were hospitalized or underwent physical examination in The People's Hospital of Xinjiang Uygur Autonomous Region from December 2017 to May 2020. Plasma Fg level was measured, and based on the previous results of whole exon sequencing of the FGB gene, the SNaPshot method was used to identify the genotype at rs4220 and rs1044291 loci of the FGB gene. The t-test was used for comparison of normally distributed continuous data between two groups, and the Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test was used for comparison of categorical data between two groups; a multivariate logistic regression analysis was used to investigate the association between each variable and gallstones.  Results  For the Chinese Han population, the gallstones group had a significantly higher plasma Fg level than the control group [2.90 (2.43-3.49) g/L vs 2.47 (2.06-3.02) g/L, Z=-3.62, P < 0.01), while there was no significant difference in the Uyghur population. There were no significant differences in the frequencies of genotypes and alleles at the rs4220 and rs1044291 loci of the FGB gene between the gallstones group and the control group in both Uyghur and Han populations (all P > 0.05). For the Chinese Han population, the subjects carrying GG genotype at the rs4220 locus in the gallstones group had a significantly higher plasma Fg level than those in the control group [2.84(2.32-3.61) g/L vs 2.34(2.05-2.75) g/L, Z=-3.04, P < 0.05], and the subjects carrying T genotype at the rs1044291 locus had a significantly higher plasma Fg level than those in the control group (3.08±0.75 g/L vs 2.48±0.48 g/L, t=2.80, P < 0.05). For the Uyghur population, only the subjects carrying A genotype at the rs4220 locus in the gallstones group had a significantly lower plasma Fg level than those in the control group [2.84(2.08-3.06) g/L vs 3.10(2.85-3.98) g/L, Z=-2.41, P < 0.05]. There was no significant difference in plasma Fg level between the subjects carrying different genotypes within the gallstones group or the control group for both Uyghur and Han populations (all P > 0.05).  Conclusion  The influence of FGB gene polymorphism on plasma Fg level may be associated with race, and FGB gene polymorphisms at the rs4220 and rs1044291 loci may be involved in the pathogenesis of gallstones by regulating Fg level in the population in Xinjiang.

     

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    • References(17)
  • [1]
    SONG J, CHEN LZ, ZHENG YY, et al. Correlation between β-fibrinogen gene-249 C / T polymorphism and coronary heart disease in Inner Mongolia[J]. J Baotou Med Coll, 2016, 32(8): 7-9. https://www.cnki.com.cn/Article/CJFDTOTAL-BTYX201608004.htm

    宋剑, 陈丽珠, 郑玉云, 等. 内蒙古地区人纤维蛋白原β-249 C/T基因多态性与冠心病的相关性[J]. 包头医学院学报, 2016, 32(8): 7-9. https://www.cnki.com.cn/Article/CJFDTOTAL-BTYX201608004.htm
    [2]
    LI JT, ZHAO HM, CHEN XH. Correlation between β-fibrinogen gene-455G/A polymorphism and plasma fibrinogen level and lacunar infraction[J]. Int J Cerebrovasc, 2019, 27(12): 902-908. DOI: 10.3760/cma.j.issn.1673-4165.2019.12.005.

    李军廷, 赵鸿梅, 陈晓虹. β-纤维蛋白原基因-455G/A多态性与血浆纤维蛋白原水平及腔隙性脑梗死的相关性[J]. 国际脑血管病杂志, 2019, 27(12): 902-908. DOI: 10.3760/cma.j.issn.1673-4165.2019.12.005.
    [3]
    QIN YL. The study of the relationships between the coagulo-fibrinolytic changes and the roles of fibrin(ogen) in cholesterol gallstone formation[D]. Nanjing: Southeast University, 2000.

    秦永林. 纤维蛋白(原)和凝血、纤溶系统在胆囊胆固醇结石形成中的作用[D]. 南京: 东南大学, 2000.
    [4]
    ZHU SZ. Therapeutic effect and related factors of human fibrinogen on traumat-ic traumatic coagulopathy[J]. Chin J Clin Pharmacol Ther, 2019, 24(6): 693-698. DOI: 10.12092/j.issn.1009-2501.2019.06.015.

    朱悚之. 人纤维蛋白原对急诊外伤致创伤性凝血病疗效及相关因素分析[J]. 中国临床药理学与治疗学, 2019, 24(6): 693-698. DOI: 10.12092/j.issn.1009-2501.2019.06.015.
    [5]
    FULLER GM, ZHANG Z. Transcriptional control mechanism of fibrinogen gene expression[J]. Ann N Y Acad Sci, 2001, 936: 469-479. DOI: 10.1111/j.1749-6632.2001.tb03534.x.
    [6]
    LIU CH, GE YL, LI LR, et al. Polymorphism of fibrinogen Bβ-249C / T gene in smokers with COPD[J]. J Bengbu Med Coll, 2020, 45(2): 201-204. DOI: 10. 13898/ j. cnki. issn. 1000-2200. 2020. 02. 017.

    刘聪辉, 戈艳蕾, 李丽蕊, 等. 慢性阻塞性肺疾病吸烟病人纤维蛋白原Bβ-249 C/T基因多态性[J]. 蚌埠医学院学报, 2020, 45(2): 201-204. DOI: 10. 13898/ j. cnki. issn. 1000-2200. 2020. 02. 017.
    [7]
    DUAN JL, ZHANG XM, MENG PF, et al. Relationship between plasma fibrinogen gene polymorphism, obesity and ischemic cerebral stroke[J]. Chin J Integr Med Cardio/Cerebrovasc Dis, 2020, 18(13): 2168-2171. DOI: 10.12102/ji.ssn.1672-1349.2020.13.040.

    段家乐, 张晓敏, 孟鹏飞, 等. 血浆纤维蛋白原基因多态性、肥胖与缺血性脑卒中的关系探讨[J]. 中西医结合心脑血管病杂志, 2020, 18(13): 2168-2171. DOI: 10.12102/ji.ssn.1672-1349.2020.13.040.
    [8]
    ONG KL, TSO AW, CHERNY SS, et al. A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men[J]. Thromb Haemost, 2010, 103(4): 728-735. DOI: 10.1160/TH09-10-0692.
    [9]
    THEODORAKI EV, NIKOPENSIUS T, SUHORUTSENKO J, et al. Fibrinogen beta variants confer protection against coronary artery disease in a Greek case-control study[J]. BMC Med Genet, 2010, 11: 28. DOI: 10.1186/1471-2350-11-28.
    [10]
    INGEBRIGTSEN TS, MAROTT JL, RODE L, et al. Fibrinogen and α1-antitrypsin in COPD exacerbations[J]. Thorax, 2015, 70(11): 1014-1021. DOI: 10.1136/thoraxjnl-2015-207561.
    [11]
    STINTON LM, MYERS RP, SHAFFER EA. Epidemiology of gallstones[J]. Gastroenterol Clin North Am, 2010, 39(2): 157-169, vii. DOI: 10.1016/j.gtc.2010.02.003.
    [12]
    MIAO YG, XUE DB, ZHANG WH. Progress of research on the causes and treatment of Cholesterol Gallstones[J]. J Hepatopancreatobiliary Surg, 2016, 28(2): 155-157, 177. DOI: 10.11952/j.issn.1007-1954.2016.02.023.

    苗彦国, 薛东波, 张伟辉. 胆囊胆固醇结石成因及其治疗研究进展[J]. 肝胆胰外科杂志, 2016, 28(2): 155-157, 177. DOI: 10.11952/j.issn.1007-1954.2016.02.023.
    [13]
    LI WD. Epidemiological analysis of gallstone in Xinjiang[J]. Contemp Med Forum, 2014, 21: 187-188. https://www.cnki.com.cn/Article/CJFDTOTAL-QYWA201421157.htm

    李卫东. 对新疆地区胆囊结石的流行病学分析[J]. 当代医药论丛, 2014, 21: 187-188. https://www.cnki.com.cn/Article/CJFDTOTAL-QYWA201421157.htm
    [14]
    BODMER M, BRAUCHLI YB, KRÄHENBÜHL S, et al. Statin use and risk of gallstone disease followed by cholecystectomy[J]. JAMA, 2009, 302(18): 2001-2007. DOI: 10.1001/jama.2009.1601.
    [15]
    ZHUANG JH, DILIMULATI, ZHOU GM, et al. Clinical analysis of 872 cases of cholelithiasis in Xinjiang[J]. J Hepatopancreatobiliary Surg, 2006, 18(1): 47-48. DOI: 10.11952/j.issn.1007-1954.2006.01.018.

    庄建华, 地里木拉提, 周贵明, 等. 新疆维吾尔族聚居区居民胆结石872例临床分析[J]. 肝胆胰外科杂志, 2006, 18(1): 47-48. DOI: 10.11952/j.issn.1007-1954.2006.01.018.
    [16]
    CANSECO-AVILA LM, LOPEZ-ROBLERO A, SERRANO-GUZMAN E, et al. Polymorphisms-455G/A and-148C/T and fibrinogen plasmatic level as risk markers of coronary disease and major adverse cardiovascular events[J]. Dis Markers, 2019, 2019: 5769514. DOI: 10.1155/2019/5769514.
    [17]
    CRONJÉ HT, NIENABER-ROUSSEAU C, ZANDBERG L, et al. Fibrinogen and clot-related phenotypes determined by fibrinogen polymorphisms: Independent and IL-6-interactive associations[J]. PLoS One, 2017, 12(11): e0187712. DOI: 10.1371/journal.pone.0187712.
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