| [1] |
HARRINGTON LE, HATTON RD, MANGAN PR, et al. Interleukin 17 producing CD4 + effector T cells develop via a lineage distinct fromthe T helper type 1 and 2 lineages[J]. Nat Immunol, 2005, 6 (11): 1123-1132. DOI: 10.1038/ni1254 |
| [2] |
HIRAHARA K, GHORESCHI K, LAURENCE A, et al. Signal transduction pathways and transcriptional regulation in Th17 cell differentiation[J]. Cytokine Growth Factor Rev, 2010, 21(6): 425-434. DOI: 10.1016/j.cytogfr.2010.10.006 |
| [3] |
YANG XO, PAPPU BP, NURIEVA R, et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma[J]. Immunity, 2008, 28(1): 29-39. DOI: 10.1016/j.immuni.2007.11.016 |
| [4] |
KIM HY, JHUN JY, CHO ML, et al. Interleukin-6 upregulates Th17 response via mTOR/STAT3 pathway in acute-on-chronic hepatitis B liver failure[J]. J Gastroenterol, 2014, 49(8): 1264-1273. DOI: 10.1007/s00535-013-0891-1 |
| [5] |
CHEN J, LIAO MY, GAO XL, et al. IL-17A induces pro-inflammatory cytokines production in macrophages via MAPKinases, NF-κB and AP-1[J]. Cell Physiol Biochem, 2013, 32(5): 1265-1274. DOI: 10.1159/000354525 |
| [6] |
SAKAGUCHI S, SAKAGUCHI N, ASANO M, et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases[J]. J Immunol, 1995, 155(3): 1151-1164.
|
| [7] |
SAKAGUCHI S. Naturally arising Foxp3-expressing CD25 +CD4 + regulatory T cells in immunological tolerance to self and non-self[J]. Nat Immunol, 2005, 6(4): 345-352. DOI: 10.1038/ni1178 |
| [8] |
LIU J, WANG CL, GU X, et al. Correlation relationship between imbalance of Th17/Treg cells and hepatitis B virus infection liver disease[J]. J North Sichuan Med Coll, 2017, 32(3): 479-482. (in Chinese) DOI: 10.3969/j.issn.1005-3697.2017.03.045 |
| [9] |
NACKA-ALEKSIC' M, STOJANOVIC' M, PILIPOVIC' I, et al. Strain differences in thymic atrophy in rats immunized for EAE correlate with the clinical outcome of immunization[J]. PLoS One, 2018, 13(8): e0201848. DOI: 10.1371/journal.pone.0201848 |
| [10] |
ZIEGLER SF, BUCKNER JH. FOXP3 and the regulation of Treg/Th17 differentiation[J]. Microbes Infect, 2009, 11(5): 594-598. DOI: 10.1016/j.micinf.2009.04.002 |
| [11] |
LI P, SPOLSKI R, LIAO W, et al. Complex interactions of transcription factors in mediating cytokine biology in T cells[J]. Immunol Rev, 2014, 261(1): 141-156. DOI: 10.1111/imr.12199 |
| [12] |
LIM HW, LEE J, HILLSAMER P, et al. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells[J]. J Immunol, 2008, 180(1): 122-129. DOI: 10.4049/jimmunol.180.1.122 |
| [13] |
SIERRO S, ROMERO P, SPEISER DE. The CD4-like molecule LAG-3, biology and therapeutic applications[J]. Expert Opin Ther Targets, 2011, 15(1): 91-101. DOI: 10.1517/14712598.2011.540563 |
| [14] |
YIN J, XU DH, FENG H. The role of Th17/Treg cells in pathogenesis and clinical outcome of chronic hepatitis B[J]. J Prac Hepatol, 2011, 14(5): 389-392. (in Chinese) DOI: 10.3969/j.issn.1672-5069.2011.05.035 |
| [15] |
PAQUISSI FC. Immunity and fibrogenesis: The role of Th17/IL-17 axis in HBV and HCV-induced chronic hepatitis and progression to cirrhosis[J]. Front Immunol, 2017, 8: 1195. DOI: 10.3389/fimmu.2017.01195 |
| [16] |
LI Z, NIE L, CHEN L, et al. Rapamycin relieves inflammation of experimental autoimmune encephalomyelitis by altering the balance of Treg/Th17 in a mouse model[J]. Neurosci Lett, 2019, 705: 39-45. DOI: 10.1016/j.neulet.2019.04.035 |
| [17] |
LU H, DAI X, LI X, et al. Gal-1 regulates dendritic cells-induced Treg/Th17 balance though NF-κB/RelB-IL-27 pathway[J]. Ann Transl Med, 2019, 7(22): 628. DOI: 10.21037/atm.2019.11.02 |
| [18] |
MURPHY KM, STOCKINGER B. Effector T cell plasticity: Flexibility in the face of changing circumstances[J]. Nat Immunol, 2010, 11(8): 674-680. DOI: 10.1038/ni.1899 |
| [19] |
IMBRATTA C, LEBLOND MM, BOUZOURÈNE H, et al. Maf deficiency in T cells dysregulates Treg - TH17 balance leading to spontaneous colitis[J]. Sci Rep, 2019, 9(1): 6135. DOI: 10.1038/s41598-019-42486-2 |
| [20] |
WU W, LI J, CHEN F, et al. Circulating Th17 cells frequency is associated with the disease progression in HBV infected patients[J]. J Gastroenterol Hepatol, 2010, 25(4): 750-757. DOI: 10.1111/j.1440-1746.2009.06154.x |
| [21] |
ZHANG H, JIANG Z, ZHANG L. Dual effect of T helper cell 17 (Th17) and regulatory T cell (Treg) in liver pathological process: From occurrence to end stage of disease[J]. Int Immunopharmacol, 2019, 69: 50-59. DOI: 10.1016/j.intimp.2019.01.005 |
| [22] |
GAO Y, ZHANG M, LI J, et al. Circulating FoxP3+ regulatory T and interleukin17-producing Th17 cells actively influence HBV clearance in de novo hepatitis B birus infected patients after orthotopic liver transplantation[J]. PLoS One, 2015, 10(9): e0137881. DOI: 10.1371/journal.pone.0137881 |
| [23] |
YI H, ZHANG Y, YANG X, et al. Hepatitis B core antigen impairs the polarization while promoting the production of inflammatory cytokines of M2 macrophages via the TLR2 pathway[J]. Front Immunol, 2020, 11: 535. DOI: 10.3389/fimmu.2020.00535 |
| [24] |
SUN XF, GU L, DENG WS, et al. Impaired balance of T helper 17/T regulatory cells in carbon tetrachloride-induced liver fibrosis in mice[J]. World J Gastroenterol, 2014, 20(8): 2062-2070. DOI: 10.3748/wjg.v20.i8.2062 |
| [25] |
LIU HE, YOU J, HONG M, et al. Study on the role of the balance Th17/Treg in the development of hepatitis B virus-related liver fibrosis[J]. Chin Gen Pract, 2016, 19(18): 2126-2129. (in Chinese) DOI: 10.3969/j.issn.1007-9572.2016.18.004 |
| [26] |
MENG F, WANG K, AOYAMA T, et al. Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice[J]. Gastroenterology, 2012, 143(3): 765-776.e3. DOI: 10.1053/j.gastro.2012.05.049 |
| [27] |
FABRE T, KARED H, FRIEDMAN SL, et al. IL-17A enhances the expression of profibrotic genes through upregulation of the TGFβ receptor on hepatic stellate cells in a JNK-dependent manner[J]. J Immunol, 2014, 193(8): 3925-3933. DOI: 10.4049/jimmunol.1400861 |
| [28] |
ROBERT S, GICQUEL T, BODIN A, et al. Characterization of the MMP/TIMP imbalance and collagen production induced by IL-1β or TNF-α release from human hepatic stellate cells[J]. PLoS One, 2016, 11(4): e0153118. DOI: 10.1371/journal.pone.0153118 |
| [29] |
LI K, LIU H, GUO T. Th17/Treg imbalance is an indicator of liver cirrhosis process and a risk factor for HCC occurrence in HBV patients[J]. Clin Res Hepatol Gastroenterol, 2017, 41(4): 399-407. DOI: 10.1016/j.clinre.2016.12.004 |
| [30] |
YANG AT, YAN XZ, ZHAO WS, et al. Molecular mechanism of elastin and its regulatory factors on the formation and reversal of liver fibrosis in a mouse model of liver fibrosis[J]. J Clin Hepatol, 2020, 36(7): 1514-1519.(in Chinese) DOI: 10.3969/j.issn.1001-5256.2020.07.014 |
| [31] |
LAN YT, WANG ZL, TIAN P, et al. Treg/Th17 imbalance and its clinical significance in patients with hepatitis B-associated liver cirrhosis[J]. Diagn Pathol, 2019, 14(1): 114. DOI: 10.1186/s13000-019-0891-4 |
| [32] |
LIANG C, BU S, FAN X. Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-β1/Smad3[J]. Cell Biochem Funct, 2016, 34(5): 326-333. DOI: 10.1002/cbf.3193 |
| [33] |
|
| [34] |
JIANG M, GONG X, XIAO XQ, et al. Expression of serum miRNA-122-3p in patients with CHB treated with PEG-interferon-alpha 2b[J]. Int J Virol, 2019, 26(5): 293-298. (in Chinese) DOI: 10.3760/cma.j.issn.1673-4092.2019.05.002 |
| [35] |
WANG YZ, ZHANG W, WANG YH, et al. Repression of liver cirrhosis achieved by inhibitory effect of miR-454 on hepatic stellate cells activation and proliferation via Wnt10a[J]. J Biochem, 2019, 165(4): 361-367. DOI: 10.1093/jb/mvy111 |
| [36] |
LITTMAN DR, RUDENSKY AY. Th17 and regulatory T cells in mediating and restraining inflammation[J]. Cell, 2010, 140(6): 845-858. DOI: 10.1016/j.cell.2010.02.021 |
| [37] |
LAN YT, FAN XP, FAN YC, et al. Change in the Treg/Th17 cell imbalance in hepatocellular carcinoma patients and its clinical value[J]. Medicine (Baltimore), 2017, 96(32): e7704. DOI: 10.1097/MD.0000000000007704 |
| [38] |
LIN ZW, WU LX, XIE Y, et al. The expression levels of transcription factors T-bet, GATA-3, RORγt and FOXP3 in peripheral blood lymphocyte (PBL) of patients with liver cancer and their significance[J]. Int J Med Sci, 2015, 12(1): 7-16. DOI: 10.7150/ijms.8352 |
| [39] |
GAO YW, CHEN YX, WANG ZM, et al. Increased expression of cyclooxygenase-2 and increased infiltration of regulatory T cells in tumors of patients with hepatocellular carcinoma[J]. Digestion, 2009, 79(3): 169-176. DOI: 10.1159/000210266 |
| [40] |
ZHOU Y, XU X, DING J, et al. Dynamic changes of T-cell subsets and their relation with tumor recurrence after microwave ablation in patients with hepatocellular carcinoma[J]. J Cancer Res Ther, 2018, 14(1): 40-45. DOI: 10.4103/jcrt.JCRT_775_17 |
| [41] |
KINOSHITA M, KOBAYASHI S, GOTOH K, et al. Heterogeneity of Treg/Th17 according to cancer progression and modification in biliary tract cancers via self-producing cytokines[J]. Dig Dis Sci, 2020, 65(10): 2937-2948. DOI: 10.1007/s10620-019-06011-9 |
| [42] |
CROCE M, RIGO V, FERRINI S. IL-21: A pleiotropic cytokine with potential applications in oncology[J]. J Immunol Res, 2015, 2015: 696578.
|
| [43] |
SHAHID A, BHARADWAJ M. The connection between the Th17 cell related cytokines and cancer stem cells in cancer: Novel therapeutic targets[J]. Immunol Lett, 2019, 213: 9-20. DOI: 10.1016/j.imlet.2019.07.001 |
| [44] |
van der HEIDE D, WEISKIRCHEN R, BANSAL R. Therapeutic targeting of hepatic macrophages for the treatment of liver diseases[J]. Front Immunol, 2019, 10: 2852. DOI: 10.3389/fimmu.2019.02852 |
| [45] |
ZHANG GL, ZHANG T, ZHAO QY, et al. Th17 cells over 5.9% at admission indicate poor prognosis in patients with HBV-related acute-on-chronic liver failure[J]. Medicine (Baltimore), 2018, 97(40): e12656. DOI: 10.1097/MD.0000000000012656 |
| [46] |
JEFFERSON B, ALI M, GRANT S, et al. Thrombospondin-1 exacerbates acute liver failure and hepatic encephalopathy pathology in mice by activating transforming growth factor β1[J]. Am J Pathol, 2020, 190(2): 347-357. DOI: 10.1016/j.ajpath.2019.10.003 |
| [47] |
HUANG B, CHENG X, WANG H, et al. Mesenchymal stem cells and their secreted molecules predominantly ameliorate fulminant hepatic failure and chronic liver fibrosis in mice respectively[J]. J Transl Med, 2016, 14: 45. DOI: 10.1186/s12967-016-0792-1 |
| [48] |
YANG R, GAO H, CHEN L, et al. Effect of peripheral blood-derived mesenchymal stem cells on macrophage polarization and Th17/Treg balance in vitro[J]. Regen Ther, 2020, 14: 275-283. DOI: 10.1016/j.reth.2020.03.008 |
DownLoad: