Correlation between systemic immune-inflammation index and prognosis in patients with hepatic alveolar echinococcosis

Xiaobin CHEN; Jiaqi YUAN; Zhixin WANG; Haining FAN; Zhaojun XU; Xuepeng MEI; Haijiu WANG; Jiamin MA; Ying ZHOU; Lizhao HOU

doi:10.3969/j.issn.1001-5256.2021.02.025

Volume 37 Issue 2

Mar. 2021

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Article Navigation > Journal of Clinical Hepatology > 2021 > 37(2): 375-379

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Correlation between systemic immune-inflammation index and prognosis in patients with hepatic alveolar echinococcosis

DOI: 10.3969/j.issn.1001-5256.2021.02.025

Xiaobin CHEN¹,
Jiaqi YUAN¹,
Zhixin WANG^{1, 2
,
,},
Haining FAN^{1, 2},
Zhaojun XU¹,
Xuepeng MEI¹,
Haijiu WANG^{1, 2},
Jiamin MA¹,
Ying ZHOU^{1, 2},
Lizhao HOU^{1, 2}

1.
Department of Hepatopancreatobiliary Surgery, Qinghai University Affiliated Hospital, Xining 810001, China
2.
Qinghai Province Key Laboratory of Hydatid Disease Research, Xining 810001, China

Received Date: 2020-08-20
Accepted Date: 2020-10-30
Published Date: 2021-02-20

Abstract

Abstract

Objective To investigate the correlation between systemic immune-inflammation index (SⅡ) and prognosis in patients with hepatic alveolar echinococcosis. Methods A retrospective analysis was performed for the clinical data of 242 patients who were admitted to Department of Hepatopancreatobiliary Surgery, Qinghai University Affiliated Hospital, from January 2015 to December 2018 and underwent surgery for hepatic alveolar echinococcosis, and SⅡ was calculated. The chi-square test was used for comparison of categorical data between two groups, and a Spearman correlation analysis was performed. The receiver operating characteristic (ROC) curve was used to determine the optimal cut-off value of SⅡ; the Kaplan-Meier method was used to plot survival curves and analyze overall survival time in the two groups, and the log-rank test was used for comparison of survival rates between the two groups; univariate and multivariate Cox regression analyses were used to identify the influencing factors for the prognosis of patients with hepatic alveolar echinococcosis. Results The Spearman correlation analysis showed that SⅡ was positively correlated with the postoperative fatality rate of patients with hepatic alveolar echinococcosis (r=0.267, P < 0.001). The ROC curve showed that the optimal cut-off value of SⅡ before surgery was 758.92, and based on this, 242 patients with hepatic alveolar echinococcosis were divided into low SⅡ (SⅡ ≤758.92) group with 126 patients and high SⅡ (SⅡ >758.92) group with 116 patients. The low SⅡ group had 1-, 3-, and 5-year survival rates of 98.20%, 88.47%, and 66.10%, respectively, and the high SⅡ group had 1-, 3-, and 5-year survival rates of 90.80%, 53.05%, and 27.40%, respectively. The low SⅡ group had a cumulative survival rate of >50% and a mean survival time of 55.584 months (95% confidence interval[CI]: 53.550-57.617), while the high SⅡ group had a cumulative survival rate of < 50%, a mean survival time of 39.384 months (95% CI: 35.070-43.698), and a median survival time of 43 months (95% CI: 34.694-51.306). The low SⅡ group had a significantly better survival rate than the high SⅡ group, and there was a significant difference in overall survival rate between the two groups (χ²=46.979, P < 0.05). The univariate analysis showed that SⅡ >758.92 (hazard ratio [HR]=5.907, 95% CI: 3.386-10.306, P=0.001) was an influencing factor for the overall survival time of patients with hepatic alveolar echinococcosis, and the multivariate Cox regression analysis showed that preoperative peripheral blood SⅡ (HR=3.507, 95% CI: 1.911-6.435, P=0.001) was an independent risk factor for the overall survival rate of patients with hepatic alveolar echinococcosis. Conclusion Preoperative SⅡ level is clearly correlated with the prognosis of patients with hepatic alveolar echinococcosis and can thus be used as a clinical indicator to evaluate the prognosis of patients. The higher the peripheral blood SⅡ before surgery, the worse the prognosis of patients.
- Echinococcosis, Hepatic,
- Systemic Immune Inflammatory,
- Prognosis,
- Risk Factors

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Correlation between systemic immune-inflammation index and prognosis in patients with hepatic alveolar echinococcosis

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Correlation between systemic immune-inflammation index and prognosis in patients with hepatic alveolar echinococcosis

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