ISSN 1001-5256
CN 22-1108/R
Volume 35 Issue 12
Dec.  2019
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Article Contents

Research advances in antioxidants in the progression of alcoholic liver disease

DOI: 10.3969/j.issn.1001-5256.2019.12.038
  • Received Date: 2019-07-24
  • Published Date: 2019-12-20
  • Alcoholic liver disease( ALD) is a series of chronic non-infectious liver diseases caused by long-term heavy alcohol consumption. Reactive oxygen species( ROS) is produced during alcohol metabolism,and if it is not eliminated completely,it may cause oxidative stress,which will further lead to inflammatory response of Kupffer cells and lipid peroxidation and thus accelerate the progression of alcoholic hepatitis and fibrosis. The human body can generate a variety of enzymes or antioxidants to eliminate ROS and its by-products and resist oxidative stress. This article reviews several enzymes or antioxidants involved in antioxidant activity in ALD.


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  • [1] CHACKO KR,REINUS J. Spectrum of alcoholic liver disease[J]. Clin Liver Dis,2016,20(3):419-427.
    [2] WHO. Global status report on alcohol and health 2018[EB/OL].[2018-9-21]. https://www. who. int/substance_abuse/publications/global_alcohol_report/en/.
    [3] SEITZ HK,BATALLER R,CORTEZ-PINTO H,et al. Alcoholic liver disease[J]. Nat Rev Dis Primers,2018,4(1):16.
    [4] YANG FN,HUANG J. Research progress in genetic susceptibility to alcoholic liver disease[J]. J Clin Hepatol,2017,33(2):379-383.(in Chinese)杨馥宁,黄晶.酒精性肝病的遗传易感性研究现状[J].临床肝胆病杂志,2017,33(2):379-383.
    [5] GAO B,ZAKHARI S. Zakim and Boyer’s hepatology[M].Philadelphia,PA:Elsevier,2018:334-344.
    [6] European Association for the Study of the Liver. EASL clinical practice guidelines:Management of alcohol-related liver disease[J]. J Hepatol,2018,69(1):154-181.
    [7] LI S,TAN HY,WANG N,et al. The role of oxidative stress and antioxidants in liver diseases[J]. Int J Mol Sci,2015,16(11):26087-26124.
    [8] LOUVET A,MATHURIN P. Alcoholic liver disease:Mechanisms of injury and targeted treatment[J]. Nat Rev Gastroenterol Hepatol,2015,12(4):231-242.
    [9] CENI E,MELLO T,GALLI A. Pathogenesis of alcoholic liver disease:Role of oxidative metabolism[J]. World J Gastroenterol,2014,20(47):17756-17772.
    [10] CEDERBAUM AI. Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications[J]. Redox Biol,2015,4:60-73.
    [11] MUELLER S,PECCERELLA T,QIN H,et al. Carcinogenic etheno DNA adducts in alcoholic liver disease:Correlation with cytochrome P-4502E1 and fibrosis[J]. Alcohol Clin Exp Res,2018,42(2):252-259.
    [12] CHEN D,LIN XX,CHEN Y. Research on the progress of alcoholic liver disease pathogenesis related to CYP2E1[J]. Chin J Clin Pharmacol Ther,2017,22(2):198-203.(in Chinese)陈丹,林秀贤,陈尧.CYP2E1调控酒精性肝病发病机制的研究进展[J].中国临床药理学与治疗学,2017,22(2):198-203.
    [13] LU Y,CEDERBAUM AI. Cytochrome P450s and alcoholic liver disease[J]. Curr Pharm Des,2018,24(14):1502-1517.
    [14] ZHAO N,GUO FF,XIE KQ,et al. Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease[J]. Cell Mol Life Sci,2018,75(17):3143-3157.
    [15] SUN J,FU J,LI L,et al. Nrf2 in alcoholic liver disease[J].Toxicol Appl Pharmacol,2018,357:62-69.
    [16] TANG W,JIANG YF,PONNUSAMY M,et al. Role of Nrf2 in chronic liver disease[J]. World J Gastroenterol,2014,20(36):13079-13087.
    [17] XIE Y,ZHOU X,CHEN L,et al. Cloning and characterization of a novel sigma-like glutathione S-transferase from the giant panda parasitic nematode,Baylisascaris schroederi[J].Parasit Vectors,2015,8:44.
    [18] HOLLMAN AL,TCHOUNWOU PB,HUANG HC. The association between gene-environment interactions and diseases involving the human GST superfamily with SNP variants[J]. Int J Environ Res Public Health,2016,13(4):379.
    [19] RUZZA P,CALDERAN A. Glutathione Transferase(GST)-activated prodrugs[J]. Pharmaceutics,2013,5(2):220-231.
    [20] BALTRUSKEVICIENE E,KAZBARIENE B,BADARAS R,et al.Glutathione and glutathione S-transferase levels in patients with liver metastases of colorectal cancer and other hepatic disorders[J]. Turk J Gastroenterol,2016,27(4):336-341.
    [21] MARI M,CEDERBAUM AI. Induction of catalase,alpha,and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress[J]. Hepatology,2001,33(3):652-661.
    [22] CHANG YC,LIU FP,MA X,et al. Glutathione S-transferase A1-a sensitive marker of alcoholic injury on primary hepatocytes[J]. Hum Exp Toxicol,2017,36(4):386-394.
    [23] BROEKMAN MM,BOS C,TE MORSCHE RH,et al. GST Theta null genotype is associated with an increased risk for ulcerative colitis:A case-control study and meta-analysis of GST Mu and GST Theta polymorphisms in inflammatory bowel disease[J]. J Hum Genet,2014,59(10):575-580.
    [24] MARCOS M,PASTOR I,CHAMORRO AJ,et al. Meta-analysis:Glutathione-S-transferase allelic variants are associated with alcoholic liver disease[J]. Aliment Pharmacol Ther,2011,34(10):1159-1172.
    [25] MANSOORI AA,JAIN SK. ADH1B,ALDH2,GSTM1 and GSTT1gene polymorphic frequencies among alcoholics and controls in the arcadian population of Central India[J]. Asian Pac J Cancer Prev,2018,19(3):725-731.
    [26] BHATTACHARJEE P,PAUL S,BANERJEE M,et al. Functional compensation of glutathione S-transferase M1(GSTM1)null by another GST superfamily member,GSTM2[J]. Sci Rep,2013,3:2704.
    [27] SCHNEKENBURGER M,KARIUS T,DIEDERICH M. Regulation of epigenetic traits of the glutathione S-transferase P1gene:From detoxification toward cancer prevention and diagnosis[J]. Front Pharmacol,2014,5:170.
    [28] KALYANARAMAN B. Teaching the basics of redox biology to medical and graduate students:Oxidants,antioxidants and disease mechanisms[J]. Redox Biol,2013,1(1):244-257.
    [29] WANG Y,BRANICKY R,NO¨EA,et al. Superoxide dismutases:Dual roles in controlling ROS damage and regulating ROS signaling[J]. J Cell Biol,2018,217(6):1915-1928.
    [30] LEWANDOWSKI,KEPINSKA M,MILNEROWICZ H. Inhibition of copper-zinc superoxide dismutase activity by selected environmental xenobiotics[J]. Environ Toxicol Pharmacol,2018,58:105-113.
    [31] HUANG YS,WANG LY,CHANG CH,et al. Superoxide dismutase 2 genetic variation as a susceptibility risk factor for alcoholic cirrhosis[J]. Alcohol Alcohol,2016,51(6):633-637.
    [32] CHENG ML,LU YF,CHEN H,et al. Liver expression of Nrf2-related genes in different liver diseases[J]. Hepatobiliary Pancreat Dis Int,2015,14(5):485-491.
    [33] SIEGEL D,GUSTAFSON DL,DEHN DL,et al. NAD(P)H:Quinone oxidoreductase 1:Role as a superoxide scavenger[J]. Mol Pharmacol,2004,65(5):1238-1247.
    [34] VIJAYAN V,WAGENER F,IMMENSCHUH S. The macrophage heme-heme oxygenase-1 system and its role in inflammation[J]. Biochem Pharmacol,2018,153:159-167.
    [35] LIU S,TIAN L,CHAI G,et al. Targeting heme oxygenase-1by quercetin ameliorates alcohol-induced acute liver injury via inhibiting NLRP3 inflammasome activation[J]. Food Funct,2018,9(8):4184-4193.
    [36] HAN KH,HASHIMOTO N,FUKUSHIMA M. Relationships among alcoholic liver disease,antioxidants,and antioxidant enzymes[J]. World J Gastroenterol,2016,22(1):37-49.
    [37] GRASSELLI E,COMPALATI AD,VOCI A,et al. Altered oxidative stress/antioxidant status in blood of alcoholic subjects is associated with alcoholic liver disease[J]. Drug Alcohol Depend,2014,143:112-119.
    [38] ZHANG H,XUE L,LI B,et al. Vitamin D protects against alcohol-induced liver cell injury within an NRF2-ALDH2 feedback loop[J]. Mol Nutr Food Res,2019,63(6):e1801014.
    [39] ZHONG ZL,ZHANG F,JIANG YH,et al. Protective effect of ferulic acid on acute liver injury[J]. Chin J Clin Pharmacol Ther,2018,23(12):1335-1339.(in Chinese)钟正灵,张飞,江玉华,等.阿魏酸对急性肝损伤的保护作用[J].中国临床药理学与治疗学,2018,23(12):1335-1339.
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