ISSN 1001-5256
CN 22-1108/R
Volume 32 Issue 1
Jan.  2016
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Article Contents

Role of hepatic sinusoids in lipopolysaccharide-induced liver injury

DOI: 10.3969/j.issn.1001-5256.2016.01.040
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  • Received Date: 2015-06-04
  • Published Date: 2016-01-20
  • Endotoxin,which is also called lipopolysaccharide( LPS),is a unique element of Gram- negative bacteria. Liver is the main site for removing bacteria and endotoxin. Meanwhile,it is also the most vulnerable organ. Liver injury initially occurs in the hepatic sinusoids. This article mainly introduces the impact of LPS on Kupffer cells,hepatic sinusoidal endothelial cells,oxidant / antioxidant balance in the hepatic sinusoids,and liver blood flow. It is believed that the function of hepatic sinusoids in LPS- induced liver injury should not be ignored,and the hepatic sinusoids would play an important role in the prevention and treatment of LPS- induced liver injury.


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