中药有效成分干预自身免疫性肝炎相关信号通路的研究进展

郝君玉; 刘光伟; 谢露; 范文艳; 陈虹秀

doi:10.3969/j.issn.1001-5256.2023.03.029

中药有效成分干预自身免疫性肝炎相关信号通路的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.03.029

1.
河南中医药大学第一临床医学院，郑州 450000
2.
河南中医药大学第一附属医院脾胃肝胆科，郑州 450000

基金项目:

国家自然科学基金资助项目 (81573933);

河南省自然科学基金 (222300420490);

河南省特色骨干学科中医学学科建设项目 (STG-ZYXKY-2020017)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：郝君玉负责文献检索，撰写论文；谢露、范文艳、陈虹秀负责资料分析；刘光伟负责指导撰写文章并最终定稿。

详细信息

通信作者:
刘光伟，Liuguangwei1975@163.com(ORCID: 0000-0002-6641-1625)

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出版历程
- 收稿日期: 2022-07-15
- 录用日期: 2022-08-26
- 出版日期: 2023-03-20

Research advances in effective constituents of traditional Chinese medicine in intervention of autoimmune hepatitis-related signaling pathways

1.
The First Clinical Medical College of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China
2.
Department of Hepatology and Spleen-Stomach, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China

Research funding:

National Natural Science Foundation of China (81573933);

Natural Science Foundation of Henan Province (222300420490);

Traditional Chinese Medicine Discipline Construction Project of Henan Province Characteristic Backbone Discipline (STG-ZYXKY-2020017)

More Information

Corresponding author: LIU Guangwei, Liuguangwei1975@163.com(ORCID: 0000-0002-6641-1625)

摘要

摘要: 自身免疫性肝炎作为一种由免疫耐受缺失导致的慢性肝脏炎症，其发病受多种信号通路的调控，例如NF-κB/NLRP3通路、SIRT1/Nrf2/HO-1通路、Hippo-YAP/TAZ通路、JAK/STAT通路、PI3K/Akt通路和TRAF6/JNK通路等，这些通路能够通过参与细胞因子的增殖和凋亡、免疫反应以及氧化应激等过程来发挥抗免疫性肝炎的作用。针对临床应用激素和免疫制剂治疗自身免疫性肝炎出现的应答不佳、不良反应明显及复发率高等问题，本文对自身免疫性肝炎相关信号传导通路的研究文献进行了总结，并梳理了苷类、萜类、黄酮类、醌类及酚类中药有效成分通过以上信号通路干预自身免疫性肝炎疾病进程的机制，以期为科学有效地利用中药有效成分研发抗自身免疫性肝炎药物提供理论参考依据。
- 肝炎, 自身免疫性 /
- 中草药 /
- 信号传导
Abstract: As a chronic liver inflammation disease caused by the lack of immune tolerance, autoimmune hepatitis is regulated by various signaling pathways, such as the NF-κB/NLRP3 pathway, the SIRT1/Nrf2/HO-1 pathway, the Hippo-YAP/TAZ pathway, the JAK/STAT pathway, the PI3K/Akt pathway, and the TRAF6/JNK pathway. These pathways can play a role against autoimmune hepatitis by participating in the processes including the proliferation and apoptosis of cytokines, immune response, and oxidative stress. In view of the problems of suboptimal response, obvious adverse reactions, and high recurrence rate in the clinical application of hormones and immune preparations for the treatment of autoimmune hepatitis, this article summarizes the research articles on autoimmune hepatitis-related signaling pathways and the mechanism of effective constituents (glycosides, terpenoids, flavonoids, quinones, and phenols) in traditional Chinese medicine intervening against the disease process of autoimmune hepatitis through the above signaling pathways, in order to provide a theoretical basis for scientific and effective utilization of effective constituents in traditional Chinese medicine to develop anti-autoimmune hepatitis drugs.
- Hepatitis, Autoimmune /
- Drugs, Chinese Herbal /
- Signal Transduction

HTML全文

图 1 相关信号通路干预AIH的作用机制

Figure 1. Mechanisms of related signaling pathways interfering with AIH

下载: 全尺寸图片幻灯片

表 1 中药有效成分干预AIH的相关信号通路

Table 1. Effective components of traditional Chinese medicine intervene in AIH-related signaling pathways

类别	名称	来源	信号通路
苷类	金线莲苷	花叶开唇兰、恒春金线莲、金线兰等	NF-κB/NLRP3、PI3K/Akt、JAK/STAT
	人参皂苷	人参、红参、三七、西洋参等	Hippo-YAP/TAZ、JAK/STAT、NF-κB
萜类	葫芦素E	药西瓜	NF-κB/NLRP3、SIRT1/Nrf2/HO-1
	雷公藤红素	雷公藤	NF-κB/NLRP3、PI3K/Akt
黄酮类	柚皮素	桃叶、菝葜、梗树果实、樱花花蕾等	NF-κB、TRAF6/JNK
醌类	丹参酮ⅡA	丹参	NF-κB、PI3K/Akt
酚类	姜黄素	姜黄、莪术、郁金等	NF-κB、Nrf2

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