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胰腺癌动物模型的比较与选择

延张励 许小凡 辛嘉萁 张红

引用本文:
Citation:

胰腺癌动物模型的比较与选择

DOI: 10.3969/j.issn.1001-5256.2022.12.044
基金项目: 

国家自然科学基金 82174201;

国家自然科学基金 82104815;

陕西中医药大学创新团队项目 2019-YL14;

陕西省特支计划 303/141020047

利益冲突声明:所有作者均声明不存在利益冲突。
作者贡献声明:延张励负责搜集数据,撰写论文;辛嘉萁参与修改论文;张红、许小凡负责指导撰写文章并最后定稿。
详细信息
    通信作者:

    张红, zhangh1227@163.com

Comparison and selection of animal models of pancreatic cancer

Research funding: 

National Natural Science Foundation of China 82174201;

National Natural Science Foundation of China 82104815;

Innovation Team Project of Shaanxi University of Traditional Chinese Medicine 2019-YL14;

Special Project in Shaanxi Province 303/141020047

More Information
  • 摘要: 胰腺癌(PC)发病隐匿、进展快、预后差,目前,其临床治疗尚无标准方案,而新的靶向治疗获益率并不明显,导致PC的死亡率极高。因此,认识PC的发生、发展机制成为目前亟待解决的首要难题,而建立可靠的PC动物模型,是深入探讨PC发生发展、侵袭、转移机制及优化有效治疗靶点的基础。目前, 大量的研究已建立了多种PC动物模型,本文现对各种常用的动物模型进行比较,为PC研究过程中动物模型的选择提供一定的参考。

     

  • 表  1  几种PC造模方式优缺点比较

    Table  1.   Comparison of advantages and disadvantages of several PC modeling methods

    造模方式 优点 缺点
    BOP诱导 费用低,操作简单易行 造模时间较长
    DMBA诱导 肿瘤进展过程与人类PC相似,便于研究各个阶段PC的发展机制 操作复杂
    原位移植 肿瘤生理特征、微环境符合实际 手术操作困难,动物死亡率高
    异位移植 费用低,操作简单,便于观察测量肿瘤大小 无法准确模拟人类PC微环境
    PDX 保留肿瘤生物学特征 建模时间长
    基因工程 肿瘤转移方式与临床相似,便于研究早期病变 建模时间长,价格昂贵,难以大规模建立
    类器官 高通量筛选,高特异性,高保真性 技术还未成熟,成本高
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