巨噬细胞耗竭及其在肝损伤中的应用

于倩; 赵赛; 刘亮明

doi:10.3969/j.issn.1001-5256.2022.12.034

巨噬细胞耗竭及其在肝损伤中的应用

DOI: 10.3969/j.issn.1001-5256.2022.12.034

南京医科大学上海松江临床医学院，上海 201615

基金项目:

国家自然科学基金 (81770612)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：于倩负责收集整合文献资料以及撰写论文；赵赛负责收集文献；刘亮明对确定写作思路及框架具有关键贡献，并且参与指导撰写、修改论文以及文章最终定稿。

详细信息

通信作者:
刘亮明，liuliangming@hotmail.com

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出版历程
- 收稿日期: 2022-04-20
- 录用日期: 2022-05-21
- 出版日期: 2022-12-20

Macrophage depletion and its application in liver injury

Songjiang Hospital Affiliated to Nanjing Medical University, Shanghai 201615, China

Research funding:

National Natural Science Foundation of China (81770612)

More Information

Corresponding author: LIU Liangming, liuliangming@hotmail.com (ORCID: 0000-0001-6001-8729)

摘要

摘要: 巨噬细胞是一种异质性细胞群，参与组织稳态、炎症和各种病理生理过程。巨噬细胞选择性地体内清除是一种被广泛接受的方法，用于研究巨噬细胞是否参与任何特定的生物学调控机制。了解不同巨噬细胞耗竭的方法及原理有助于探索研究巨噬细胞和疾病关系的合适的建模方案。肝巨噬细胞在肝毒性中起着至关重要的作用。本文就巨噬细胞耗竭的方法及巨噬细胞耗竭后在肝损伤和修复中的调节作用进行综述。
- 枯否细胞 /
- 巨噬细胞 /
- 肝损伤
Abstract: Macrophages are a heterogeneous cell population involved in tissue homeostasis, inflammation, and various pathophysiological processes. Selective clearance of macrophages in vivo is a widely accepted method used to investigate whether macrophages are involved in any specific biological regulatory mechanism. Understanding the different methods and principles of macrophage depletion helps explore appropriate modeling solutions to investigate the relationship between macrophages and diseases. Hepatic macrophages play a crucial role in hepatotoxicity. This article reviews the methods of macrophage depletion and the regulatory role of macrophage depletion in liver injury and repair.
- Kupffer Cells /
- Macrophage /
- Liver Injury

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图 1 巨噬细胞耗竭的肝保护作用机制

注：LncRNA-H19，长链非编码RNA-H19；MMP-12，基质金属蛋白酶-12。

Figure 1. Liver protective mechanisms of macrophage depletion

下载: 全尺寸图片幻灯片

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