PD-1/PD-L1免疫抑制剂在HBV感染相关肝细胞癌中的有效性及安全性分析

程然; 徐小元

doi:10.3969/j.issn.1001-5256.2022.09.041

PD-1/PD-L1免疫抑制剂在HBV感染相关肝细胞癌中的有效性及安全性分析

DOI: 10.3969/j.issn.1001-5256.2022.09.041

程然¹,
徐小元^2, , ,

1.
北京大学第三医院感染疾病科，北京 100191
2.
北京大学第一医院消化内科，北京 100034

基金项目:

国家科技重大专项课题艾滋病和病毒性肝炎等重大传染病防治 (10302201-004-009);

国家科技重大专项课题艾滋病和病毒性肝炎等重大传染病防治 (2017ZX10203202-003);

消化系统炎性疾病新药临床评价技术平台建设 (2018ZX09201016);

北京市科技计划 (D171100003117005);

北京市科技计划 (D161100002716002);

北京市科技计划 (D161100002716003)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：程然、徐小元负责课题设计，资料分析，撰写论文；徐小元负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
徐小元，xiaoyuanxu6@163.com

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出版历程
- 收稿日期: 2022-02-07
- 录用日期: 2022-04-06
- 出版日期: 2022-09-20

Efficacy and safety of programmed death-1/programmed death-ligand 1 inhibitors in treatment of hepatitis B virus-associated hepatocellular carcinoma

Ran CHENG¹,
Xiaoyuan XU^{2
, ,
,}

1.
Department of Infectious Diseases, Peking University Third Hospital, Beijing 100191, China
2.
Department of Gastroenterology, Peking University First Hospital, Beijing 100034, China

Research funding:

The National Science and Technology Major Project for Infectious Diseases (10302201-004-009);

The National Science and Technology Major Project for Infectious Diseases (2017ZX10203202-003);

National Science and Technology Major Special Project for New Drug Development (2018ZX09201016);

Beijing Municipal Science and Technology Commission of Major Projects (D171100003117005);

Beijing Municipal Science and Technology Commission of Major Projects (D161100002716002);

Beijing Municipal Science and Technology Commission of Major Projects (D161100002716003)

More Information

Corresponding author: XU Xiaoyuan, xiaoyuanxu6@163.com(ORCID: 0000-0002-1759-4330)

摘要

摘要: 基于免疫检查点抑制剂特别是程序性细胞死亡蛋白1(PD-1)及程序性死亡受体配体1(PD-L1)抑制剂的肝细胞癌(HCC)免疫联合治疗在临床研究和临床实践中已取得了显著的疗效，HBV感染被认为是HCC发生过程中的主要危险因素。PD-1/PD-L1免疫检查点抑制剂单药和联合治疗HBV相关HCC患者的安全性和有效性正在研究中，部分研究发现HBV相关HCC患者接受PD-1/PD-L1抑制剂治疗显示出与未感染HBV者相似的效果，但关于HBV激活相关的安全性问题尚未得出一致结论。在此，本文系统回顾了PD-1/PD-L1阻断免疫疗法应用于HCC的临床试验，以阐明这种新型治疗方案在特定HBV感染情况下的安全性和有效性。
- 乙型肝炎病毒 /
- 癌, 肝细胞 /
- 程序性细胞死亡受体1 /
- 免疫疗法
Abstract: Combined immunotherapy for hepatocellular carcinoma (HCC) based on immune checkpoint inhibitors (ICIs), especially programmed death receptor-1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors, has achieved a remarkable clinical effect in clinical research and practice. Hepatitis B virus (HBV) infection is considered a major risk factor in the process of HCC. Studies are being conducted to investigate the efficacy and safety of PD-1/PD-L1 ICIs used alone or in combination in the treatment of patients with HBV-associated HCC, and some studies have shown that the patients with HBV-associated HCC receiving PD-1/PD-L1 inhibitors have achieved a similar treatment outcome to those without HBV infection; however, no consensus has been reached on the safety issues related to HBV activation. This article reviews the clinical trials of PD-1/PD-L1 blockade immunotherapy for HCC, so as to clarify the safety and efficacy of this new treatment regimen in the particular circumstances of HBV infection.
- Hepatitis B Virus /
- Carcinoma, Hepatocellular /
- Programmed Cell Death 1 Receptor /
- Immunotherapy

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参考文献(42)

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