肝硬化失代偿与“再代偿”

何志颖; 王冰琼; 尤红

doi:10.3969/j.issn.1001-5256.2022.05.006

肝硬化失代偿与“再代偿”

DOI: 10.3969/j.issn.1001-5256.2022.05.006

首都医科大学附属北京友谊医院肝病中心，国家消化系统疾病临床医学研究中心，北京 100050

基金项目:

国家自然科学基金 (82000568)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：何志颖负责文献检索，撰写文章；王冰琼指导文章撰写，修改文章关键内容；尤红拟定写作思路并最终定稿。

详细信息

通信作者:
尤红，youhongliver@ccmu.edu.cn

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出版历程
- 收稿日期: 2022-03-20
- 录用日期: 2022-04-21
- 出版日期: 2022-05-20

Liver cirrhosis: Decompensation and "recompensation"

Liver Research Center, National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

Research funding:

National Natural Science Foundation of China (82000568)

More Information

Corresponding author: YOU Hong, youhongliver@ccmu.edu.cn(ORCID: 0000-0001-9409-1158)

摘要

摘要: 肝硬化分期评价体系从关注疾病进展规律到进一步细化急性失代偿时疾病状态分类，提出病因治疗后失代偿期肝硬化可再代偿的概念，系统补充了失代偿期肝硬化分期评价体系，其中门静脉高压、系统性炎症变化等多种因素可影响失代偿期肝硬化的临床转归。肝硬化再代偿这一新概念的提出，需要更多的临床证据去阐明包括病毒性肝炎等在内的病因治疗后获得“再代偿”患者的临床特征及其潜在的机制。
- 肝硬化 /
- 失代偿 /
- 再代偿
Abstract: The evolution concept of decompensated cirrhosis rebuilds the clinical staging system for decompensated cirrhosis, which changes the focus from the pattern of disease progression to refining the status of acute decompensation onset and proposing "recompensation" of decompensated cirrhosis. During the process, factors such as portal hypertension and systemic inflammatory changes can affect the clinical outcome of decompensated cirrhotic patients. Significantly, more evidence is warranted to elucidate the clinical characteristics and potential mechanisms of achieving "recompensation" after etiology control, such as in viral hepatitis patients.
- Liver Cirrhosis /
- Decompensation /
- Recompensation

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参考文献(37)

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