饮食-肠道菌群轴对非酒精性脂肪性肝病的影响

曾胜澜; 张荣臻; 王娜; 王挺帅; 谭丽婷; 毛德文

doi:10.3969/j.issn.1001-5256.2021.11.041

饮食-肠道菌群轴对非酒精性脂肪性肝病的影响

DOI: 10.3969/j.issn.1001-5256.2021.11.041

1.
广西中医药大学第一临床医学院，南宁 530023
2.
广西中医药大学第一附属医院肝病一区，南宁 530023

基金项目:

国家自然科学基金 (81960841);

国家自然科学基金 (81774236);

国家自然科学基金 (82060848);

广西自然科学基金 (2020JJA140273);

广西科技计划项目 (GK AD17129001);

国家中医药管理局"慢性重型肝炎解毒化瘀"重点研究室

详细信息

通信作者:
毛德文，mdwboshi2005@163.com

中图分类号: R575.5
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- 文章访问数: 400
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- 被引次数: 0
出版历程
- 收稿日期: 2021-03-12
- 录用日期: 2021-03-31
- 出版日期: 2021-11-20

Effect of diet-gut microbiota axis on nonalcoholic fatty liver disease

1.
The First Clinical Medical College of Guangxi University of Chinese Medicine, Nanning 530023, China
2.
Division I of Liver Disease, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning 530023, China

Research funding:

National Natural Science Foundation of China (81960841);

National Natural Science Foundation of China (81774236);

National Natural Science Foundation of China (82060848);

National Natural Science Foundation of Guangxi Province (2020JJA140273);

Guangxi Science and Technology Program Project (GK AD17129001);

State Administration of Traditional Chinese Medicine Key Laboratory of Detoxicating and Stasis-resolving Therapy for Severe Chronic Hepatitis

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)发病率日益增高。饮食被认为是调节肠道菌群组成的主要驱动力之一，肠道和肝脏通过门静脉联系密切，因此肠道微生物群的改变可能影响肝功能，促进炎症，胰岛素抵抗和脂肪变性，从而引起NAFLD。将重点讨论饮食、肠道菌群和肝脏之间的关系，以及该轴如何促进NAFLD的进展，并总结由于肠道菌群失调而引起的潜在机制改变及相关治疗。
- 非酒精性脂肪性肝病 /
- 胃肠道微生物组 /
- 健康膳食
Abstract: The incidence rate of nonalcoholic fatty liver disease (NAFLD) is increasing. Diet is considered one of the main driving forces regulating the composition of intestinal microbiota, and the intestine and the liver are closely linked through the portal vein, so changes in gut microbiota may affect liver function and promote inflammation, insulin resistance, and steatosis, thereby causing NAFLD. This article elaborates on the relationship between diet, gut microbiota, and the liver and the research advances in how this axis promotes the progression of NAFLD, as well as the change in potential mechanism due to intestinal dysbacteriosis and related treatment methods.
- Non-alcoholic Fatty Liver Disease /
- Gastrointestinal Microbiome /
- Healthy Diet

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