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药物性肝衰竭的临床特点及诊治策略

赖荣陶 谢青

赖荣陶,谢青. 药物性肝衰竭的临床特点及诊治策略[J]. 临床肝胆病杂志, 2021, 37(11): 2534-2538. DOI: 10.3969/j.issn.1001-5256.2021.11.006.
引用本文: 赖荣陶,谢青. 药物性肝衰竭的临床特点及诊治策略[J]. 临床肝胆病杂志, 2021, 37(11): 2534-2538. DOI: 10.3969/j.issn.1001-5256.2021.11.006.
LAI RT, XIE Q. Clinical features of drug-induced liver failure and related diagnosis and treatment strategies [J]. J Clin Hepatol, 2021, 37(11): 2534-2538. DOI: 10.3969/j.issn.1001-5256.2021.11.006.
Citation: LAI RT, XIE Q. Clinical features of drug-induced liver failure and related diagnosis and treatment strategies [J]. J Clin Hepatol, 2021, 37(11): 2534-2538. DOI: 10.3969/j.issn.1001-5256.2021.11.006.

药物性肝衰竭的临床特点及诊治策略

DOI: 10.3969/j.issn.1001-5256.2021.11.006
基金项目: 

国家自然科学基金项目 82070604;

国家自然科学基金项目 81770587;

国家自然科学基金项目 81970514;

上海市卫生健康委员会科研面上项目 202040111;

上海市临床重点专科(感染病学) shslczdzk01103;

十三五“科技部重大专项” 2017ZX10203201-008;

十三五“科技部重大专项” 2018ZX09201016-003-001;

十三五“科技部重大专项” 2017ZX10202202-005-004

详细信息
    通信作者:

    谢青,xieqingrjh@163.com

  • 中图分类号: R575

Clinical features of drug-induced liver failure and related diagnosis and treatment strategies

Research funding: 

National Natural Science Foundation of China 82070604;

National Natural Science Foundation of China 81770587;

National Natural Science Foundation of China 81970514;

Shanghai Municipal Planning Commission of science and Research Fund 202040111;

Shanghai Municipal Key Clinical Specialty shslczdzk01103;

Major Projects of the Ministry of Science and Technology during the 13th Five-Year Plan period 2017ZX10203201-008;

Major Projects of the Ministry of Science and Technology during the 13th Five-Year Plan period 2018ZX09201016-003-001;

Major Projects of the Ministry of Science and Technology during the 13th Five-Year Plan period 2017ZX10202202-005-004

  • 摘要: 药物性肝损伤(DILI)发生率逐年上升,其中药物相关的肝衰竭病情严重、治疗手段有限、病死率高,应引起临床医师的高度重视。对乙酰氨基酚(APAP)是西方国家急性肝衰竭(ALF)的最常见原因,除此之外,由于目前缺乏对宿主易感性和发病机制的深入了解,特异性DILI诱发的ALF患者早期不易被识别,自发恢复率低,预后更为凶险,已成为多个国家紧急肝移植的主要适应征。全面了解药物性肝衰竭的临床特征和预后,寻求新的可靠诊断方法和有效的治疗策略对降低药物相关肝衰竭的疾病负担至关重要。

     

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  • 收稿日期:  2021-09-15
  • 录用日期:  2021-09-15
  • 出版日期:  2021-11-20
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