靶向适应性免疫治愈慢性乙型肝炎策略及进展

朱伟; 张小勇; 张大千; 侯金林

doi:10.3969/j.issn.1001-5256.2021.05.005

靶向适应性免疫治愈慢性乙型肝炎策略及进展

DOI: 10.3969/j.issn.1001-5256.2021.05.005

南方医科大学南方医院感染内科肝病中心，广州 510515

基金项目:

国家自然科学基金 (81871664);

国家自然科学基金 (81802449)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：朱伟、张小勇、张大千、侯金林负责提出研究选题，撰写论文和修订论文。

详细信息

作者简介:
朱伟(1986—)，男，副研究员，博士，主要从事肝病细胞免疫治疗研究

通信作者:
侯金林，jlhousmu@163.com

中图分类号: R512.62
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- 文章访问数: 502
- HTML全文浏览量: 130
- PDF下载量: 121
- 被引次数: 0
出版历程
- 收稿日期: 2021-03-26
- 录用日期: 2021-04-14
- 出版日期: 2021-05-20

Strategies and advances in targeting adaptive immunity to cure chronic hepatitis B

Center of Hepatology, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China

摘要

摘要: 慢性乙型肝炎(CHB)是全球重大公共卫生问题，虽然直接抗病毒药物可以控制HBV复制但难以实现治愈CHB。宿主适应性免疫应答在清除HBV过程中发挥关键作用，通过重建患者适应性免疫有望实现CHB的功能性治愈。治疗性疫苗、细胞免疫治疗、免疫检查点阻滞、T淋巴细胞代谢重编程、中和抗体靶向适应性免疫治疗乙型肝炎的策略取得较大进展。总结了近年来上述乙型肝炎的疗法。
- 乙型肝炎病毒 /
- 乙型肝炎, 慢性 /
- 适应性免疫 /
- 治疗学
Abstract: Chronic hepatitis B (CHB) is a major global public health issue, and although direct-acting antiviral agents can control hepatitis B virus (HBV) replication, it is difficult to achieve the cure of CHB. Host adaptive immune response plays a key role in eliminating HBV, and it is expected to achieve the functional cure of CHB by rebuilding the patient's adaptive immunity. Great progress has been made in therapeutic vaccines, cellular immunotherapy, immune checkpoint blockade, T cell metabolic reprogramming, and strategies of neutralizing antibody targeting adaptive immunity for the treatment of hepatitis B. This article summarizes the above-mentioned therapies for hepatitis B in recent years.
- Hepatitis B Virus /
- Hepatitis B, Chronic /
- Adaptive Immunity /
- Therapeutics

HTML全文

图 1 靶向适应性免疫系统治愈CHB策略

下载: 全尺寸图片幻灯片

表 1 靶向适应性免疫系统治疗CHB的临床试验

名称	类型	公司	阶段
GS-4774	疫苗	Gilead Sciences	Ⅱ期
HB-110	疫苗	Genexine	Ⅰ期
TG1050	疫苗	Transgene	Ⅰ期
NASVAC	疫苗	Abivax S.A.	Ⅲ期
LTCR-H1-2	TCR-T	LION TCR	Ⅰ期
IMV-I109V	ImmTAV	Immunocore	Ⅰ/Ⅱ期
Nivolumab	免疫检查点阻滞	Bristol-Myers Squibb	Ⅰ期
GS-4224	免疫检查点阻滞	Gilead Sciences	Ⅰ期
VIR-3434	中和抗体	Vir Biotechnology	Ⅰ期

下载: 导出CSV

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