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碳酸氢根伞在原发性胆汁性胆管炎发病机制中的作用

常英昊 景丹 徐文姣 周晓蕾 王孝平 汤善宏

常英昊, 景丹, 徐文姣, 等. 碳酸氢根伞在原发性胆汁性胆管炎发病机制中的作用[J]. 临床肝胆病杂志, 2021, 37(3): 714-717. DOI: 10.3969/j.issn.1001-5256.2021.03.043
引用本文: 常英昊, 景丹, 徐文姣, 等. 碳酸氢根伞在原发性胆汁性胆管炎发病机制中的作用[J]. 临床肝胆病杂志, 2021, 37(3): 714-717. DOI: 10.3969/j.issn.1001-5256.2021.03.043
CHANG YH, JING D, XU WJ, et al. Role of HCO3- umbrella in the pathogenesis of primary biliary cholangitis[J]. J Clin Hepatol, 2021, 37(3): 714-717. DOI: 10.3969/j.issn.1001-5256.2021.03.043
Citation: CHANG YH, JING D, XU WJ, et al. Role of HCO3- umbrella in the pathogenesis of primary biliary cholangitis[J]. J Clin Hepatol, 2021, 37(3): 714-717. DOI: 10.3969/j.issn.1001-5256.2021.03.043

碳酸氢根伞在原发性胆汁性胆管炎发病机制中的作用

DOI: 10.3969/j.issn.1001-5256.2021.03.043
基金项目: 

西部战区总医院军事医学研究项目 2019ZY03

详细信息
    作者简介:

    常英昊(1992—),男,主治医师,博士,主要从事肝脏疾病相关基础与临床研究

    通讯作者:

    汤善宏,shanhongtang@163.com

  • 利益冲突声明: 所有作者均声明不存在利益冲突。
  • 作者贡献声明:常英昊负责收集分析文献与论文撰写,同时参与拟定了写作思路;景丹、徐文姣参与了收集分析文献以及论文修改;周晓蕾、王孝平参与了收集分析文献;汤善宏负责拟定写作思路,指导撰写文章与最后定稿。
  • 中图分类号: R575.7

Role of HCO3- umbrella in the pathogenesis of primary biliary cholangitis

  • 摘要: 原发性胆汁性胆管炎(PBC)是一种自身免疫性疾病。虽然PBC具有自身免疫性疾病的特征,但是免疫抑制剂对其疗效不佳,而熊去氧胆酸等参与调节胆汁酸代谢的药物却具有良好疗效。研究显示PBC患者胆管上皮细胞的碳酸氢根(HCO3-)分泌功能受损,失去HCO3-伞阻挡的胆汁酸进入胆管上皮细胞并介导细胞损伤与凋亡,引发凋亡细胞表达自身抗原并造成免疫损伤。为探究胆管上皮细胞所分泌的HCO3-伞在PBC发病机制中的作用, 简述了HCO3-伞的生理功能与产生机制,以及HCO3-分泌的影响因素等,并指出HCO3-分泌减少可能是PBC发病机制的关键环节和潜在治疗靶点。
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出版历程
  • 收稿日期:  2020-09-03
  • 修回日期:  2020-10-22
  • 刊出日期:  2021-03-16
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