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环状RNA在肝细胞癌发生发展中的作用

蔡馨 陈娟娟 汤冬玲 张平安

蔡馨, 陈娟娟, 汤冬玲, 等. 环状RNA在肝细胞癌发生发展中的作用[J]. 临床肝胆病杂志, 2021, 37(3): 695-698. DOI: 10.3969/j.issn.1001-5256.2021.03.039
引用本文: 蔡馨, 陈娟娟, 汤冬玲, 等. 环状RNA在肝细胞癌发生发展中的作用[J]. 临床肝胆病杂志, 2021, 37(3): 695-698. DOI: 10.3969/j.issn.1001-5256.2021.03.039
CAI X, CHEN JJ, TANG DL, et al. Role of circular RNA in the development and progression of hepatocellular carcinoma[J]. J Clin Hepatol, 2021, 37(3): 695-698. DOI: 10.3969/j.issn.1001-5256.2021.03.039
Citation: CAI X, CHEN JJ, TANG DL, et al. Role of circular RNA in the development and progression of hepatocellular carcinoma[J]. J Clin Hepatol, 2021, 37(3): 695-698. DOI: 10.3969/j.issn.1001-5256.2021.03.039

环状RNA在肝细胞癌发生发展中的作用

DOI: 10.3969/j.issn.1001-5256.2021.03.039
基金项目: 

国家自然科学基金 81773444

湖北省自然科学基金 2019CFC846

详细信息
    作者简介:

    蔡馨(1998—),女,主要从事环状RNA在肝细胞癌中调节作用的相关研究

    通讯作者:

    张平安,zhangpingan927@163.com

  • 利益冲突声明:所有作者均声明不存在利益冲突。
  • 作者贡献声明:蔡馨负责资料分析,撰写论文;陈娟娟、汤冬玲参与文献搜集,修改论文;张平安负责拟定写作思路,指导撰写文章并最后定稿。
  • 中图分类号: R735.7

Role of circular RNA in the development and progression of hepatocellular carcinoma

  • 摘要: 肝细胞癌(HCC)是世界上常见的恶性肿瘤之一,研究调控HCC的侵袭迁移机制对于其临床诊断和治疗具有重要意义。环状RNA(circRNA)作为非编码RNA家族的重要成员,因其环状结构高度稳定,在肝细胞中起microRNA(miRNA)海绵作用,以竞争内源性RNA机制调控miRNA或促进靶基因表达,在HCC进展中起重要作用。探讨circRNA在HCC发病中的作用机制,将有助于筛选HCC诊断标志物和研发治疗的有效靶点。
  • 表  1  与HCC相关的circRNA

    circRNA 文献 作用机制
    circRHOT1 [26] circRHOT1通过启动NR2F6促进HCC的发展
    circTRIM33-12 [27] circTRIM33-12充当miR-191的海绵抑制HCC进展
    circASAP1 [28] circASAP1通过miR-326/miR-532-5p-MAPK1/CSF-1通路调控HCC进展
    circMAT2B [29] 缺氧条件下,circMAT2B通过激活circMAT2B/miR-338-3p/PKM2轴来增强糖酵解,促进HCC进展
    hsa_circ_0091570 [30] hsa_circ_0091570作为hsa-miR-1307的分子海绵抑制HCC发展
    circ-CDYL [31] circ-CDYL在HCC早期作为miR-892a和miR-328-3p的分子海绵上调,可作为分子标志物
    cSMARCA5 [21] cSMARCA5作为miR-17-3p和miR-181b-5p的分子海绵抑制HCC进展
    hsa-circRNA-103809 [32] hsa-circRNA-103809通过螯合miR-1270和上调PLAGL2促进HCC的发展
    circHECTD1 [33] circHECTD1通过miR-485-5p上调MUC1表达来促进HCC的发展
    circ_0091579 [34] circ_0091579通过miR-490-5p/CASC3轴在HCC中部分促进了细胞的增殖、迁移、侵袭和糖酵解
    circ-DENND4C [35] circ-DENND4C通过使miR-195-5p海绵化而上调TCF4来调节肝癌细胞的增殖和死亡
    circNFATC3 [36] circNFATC3可使miR-548I保护NFATC3,然后通过JNK、c-Jun、AKT和mTOR信号通路调节HCC,可作为HCC的肿瘤抑制因子
    circ_KIAA1429 [37] circ_KIAA1429可通过m6A-YTHDF3-Zeb1的机制促进HCC进展
    hsa_circ_0026134 [38] hsa_circ_0026134下调促进miR-127-5p表达,从而抑制TRIM25和IGF2BP3介导的HCC细胞增殖和侵袭
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  • 收稿日期:  2020-08-14
  • 修回日期:  2020-09-14
  • 刊出日期:  2021-03-16
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