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环状RNA在肝细胞癌发生发展中的作用
DOI: 10.3969/j.issn.1001-5256.2021.03.039
利益冲突声明：所有作者均声明不存在利益冲突。
作者贡献声明：蔡馨负责资料分析，撰写论文；陈娟娟、汤冬玲参与文献搜集，修改论文；张平安负责拟定写作思路，指导撰写文章并最后定稿。
Role of circular RNA in the development and progression of hepatocellular carcinoma
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摘要: 肝细胞癌(HCC)是世界上常见的恶性肿瘤之一，研究调控HCC的侵袭迁移机制对于其临床诊断和治疗具有重要意义。环状RNA(circRNA)作为非编码RNA家族的重要成员，因其环状结构高度稳定，在肝细胞中起microRNA(miRNA)海绵作用，以竞争内源性RNA机制调控miRNA或促进靶基因表达，在HCC进展中起重要作用。探讨circRNA在HCC发病中的作用机制，将有助于筛选HCC诊断标志物和研发治疗的有效靶点。Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, and the study on the regulatory mechanisms of the invasion and migration of HCC is of great significance to clinical diagnosis and treatment. Circular RNA (circRNA), as an important member of the non-coding RNA family, plays the role of microRNA (miRNA) sponge in hepatocytes due to its highly stable circular structure. It also plays an important role in HCC progression by regulating miRNA or promoting the expression of target genes through the competitive endogenous RNA mechanism. This article explores the mechanism of action of circRNA in the pathogenesis of HCC, so as to help with the screening for diagnostic markers of HCC and the development of effective therapeutic targets for HCC.
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Key words:
- Carcinoma, Hepatocellular /
- CircRNA /
- Diagnosis /
- Therapeutics
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表 1 与HCC相关的circRNA
circRNA 文献 作用机制 circRHOT1 [26] circRHOT1通过启动NR2F6促进HCC的发展 circTRIM33-12 [27] circTRIM33-12充当miR-191的海绵抑制HCC进展 circASAP1 [28] circASAP1通过miR-326/miR-532-5p-MAPK1/CSF-1通路调控HCC进展 circMAT2B [29] 缺氧条件下，circMAT2B通过激活circMAT2B/miR-338-3p/PKM2轴来增强糖酵解，促进HCC进展 hsa_circ_0091570 [30] hsa_circ_0091570作为hsa-miR-1307的分子海绵抑制HCC发展 circ-CDYL [31] circ-CDYL在HCC早期作为miR-892a和miR-328-3p的分子海绵上调，可作为分子标志物 cSMARCA5 [21] cSMARCA5作为miR-17-3p和miR-181b-5p的分子海绵抑制HCC进展 hsa-circRNA-103809 [32] hsa-circRNA-103809通过螯合miR-1270和上调PLAGL2促进HCC的发展 circHECTD1 [33] circHECTD1通过miR-485-5p上调MUC1表达来促进HCC的发展 circ_0091579 [34] circ_0091579通过miR-490-5p/CASC3轴在HCC中部分促进了细胞的增殖、迁移、侵袭和糖酵解 circ-DENND4C [35] circ-DENND4C通过使miR-195-5p海绵化而上调TCF4来调节肝癌细胞的增殖和死亡 circNFATC3 [36] circNFATC3可使miR-548I保护NFATC3，然后通过JNK、c-Jun、AKT和mTOR信号通路调节HCC，可作为HCC的肿瘤抑制因子 circ_KIAA1429 [37] circ_KIAA1429可通过m6A-YTHDF3-Zeb1的机制促进HCC进展 hsa_circ_0026134 [38] hsa_circ_0026134下调促进miR-127-5p表达，从而抑制TRIM25和IGF2BP3介导的HCC细胞增殖和侵袭 
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