雌激素及其受体在非酒精性脂肪性肝病发生发展中的作用机制

彭娟; 李良平

doi:10.3969/j.issn.1001-5256.2021.02.046

雌激素及其受体在非酒精性脂肪性肝病发生发展中的作用机制

DOI: 10.3969/j.issn.1001-5256.2021.02.046

彭娟¹,
李良平^2, ,

1.
川北医学院消化内科，四川南充 637000
2.
四川省医学科学院·四川省人民医院消化内科，成都 610072

基金项目:

四川省卫计委重点课题 (16ZD024)

作者贡献声明：彭娟负责收集、阅读、筛选文献，撰写论文；李良平负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

作者简介:
彭娟(1995—)，女，主要从事非酒精性脂肪性肝病研究

通信作者:
李良平，18981838872@163.com

中图分类号: R575.5
计量
- 文章访问数: 459
- HTML全文浏览量: 106
- PDF下载量: 34
- 被引次数: 0
出版历程
- 收稿日期: 2020-07-08
- 录用日期: 2020-08-18
- 出版日期: 2021-02-20

Mechanism of action of estrogen and its receptor in the development and progression of nonalcoholic fatty liver disease

Juan PENG¹,
Liangping LI^{2
, ,}

1.
Department of Gastroenterology, Chuanbei Medical College, Nanchong, Sichuan 637000, China
2.
Department of Gastroenterology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu 610072, China

摘要

摘要: 非酒精性脂肪性肝病(NAFLD)的发病率剧增，目前仍然缺乏有效的药物治疗。虽然对NAFLD发病相关机制研究取得了巨大进展，但对NAFLD的性别差异的理解依然不够。雌激素作为重要的性激素，通过调节情绪及能量稳态、脂肪组织功能及分布、炎症反应、胰岛素抵抗、肝脂蓄积、肝脏免疫等影响NAFLD的发生及发展。充分认识雌激素及雌激素受体在NAFLD中的作用机制，为NAFLD的治疗提供新思路。
- 非酒精性脂肪性肝病 /
- 雌激素类 /
- 受体, 雌激素
Abstract: The incidence rate of nonalcoholic fatty liver disease (NAFLD) has increased sharply, and there is still a lack of effective pharmacotherapy at present. Although great achievements have been made in the research on the pathogenesis of NAFLD, we still do not know enough about the gender differences of NAFLD. As an important sex hormone, estrogen affects the development and progression of NAFLD by regulating mood and energy homeostasis, adipose tissue function and distribution, inflammatory response, insulin resistance, liver fat accumulation, and liver immunity. An adequate understanding of the mechanism of action of estrogen and its receptor in NAFLD may provide new ideas for the treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Estrogens /
- Receptors, Estrogen

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参考文献(45)

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